A Noninvasive Blood-based Combinatorial Proteomic Biomarker Assay to Detect Breast Cancer in Women Under the Age of 50 Years

Micro-Abstract To improve breast cancer diagnosis, 2 prospective clinical trials were conducted to test (n = 351) and validate (n = 210) Videssa Breast. If used in conjunction with imaging, Videssa Breast could have reduced unnecessary biopsies by up to 67%. These results support the joint use of br...

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Veröffentlicht in:	Clinical breast cancer 2017-11, Vol.17 (7), p.516-525.e6
Hauptverfasser:	Lourenco, Ana P, Benson, Kasey L, Henderson, Meredith C, Silver, Michael, Letsios, Elias, Tran, Quynh, Gordon, Kelly J, Borman, Sherri, Corn, Christa, Mulpuri, Rao, Smith, Wendy, Alpers, Josie, Costantini, Carrie, Rohatgi, Nitin, Yang, Rebecca, Haythem, Ali, Biren, Shah, Morris, Michael, Kass, Fred, Reese, David E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biomarkers, Tumor - blood Biopsies Breast Neoplasms - blood Breast Neoplasms - diagnosis Breast Neoplasms - diagnostic imaging Carcinoma in Situ - blood Carcinoma in Situ - diagnosis Carcinoma in Situ - diagnostic imaging Carcinoma, Lobular - blood Carcinoma, Lobular - diagnosis Carcinoma, Lobular - diagnostic imaging Female Follow-Up Studies Hematology, Oncology and Palliative Medicine Humans Imaging Liquid biopsy Mammography - methods Middle Aged Multimodal Imaging - methods Obstetrics and Gynecology Prognosis Prospective Studies Proteome - analysis Proteomics - methods Serum proteins Tumor-associated autoantibodies
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Beschreibung
Zusammenfassung:	Micro-Abstract To improve breast cancer diagnosis, 2 prospective clinical trials were conducted to test (n = 351) and validate (n = 210) Videssa Breast. If used in conjunction with imaging, Videssa Breast could have reduced unnecessary biopsies by up to 67%. These results support the joint use of breast imaging and Videssa Breast to better inform clinical decisions for women under age 50.
ISSN:	1526-8209 1938-0666
DOI:	10.1016/j.clbc.2017.05.004