Early bony changes associated with bisphosphonate-related osteonecrosis of the jaws in rats: a longitudinal in vivo study

Highlights • This animal study design was successful in inducing MRONJ. • Tb.Th and BV/TV should be further investigated as potential early bone markers of MRONJ. • Bony changes were detected before the dental extraction in the ZA group.

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Veröffentlicht in:	Archives of oral biology 2017-10, Vol.82, p.79-85
Hauptverfasser:	da Silva Vilarinho, Josy Lorena Peres, Ferrare, Nathália, Moreira, Andreia Maria Rocha, Moura, Helora Freitas, Acevedo, Ana Carolina, Chaves, Sacha Braun, de Melo, Nilce Santos, Leite, André Ferreira, Macedo, Sérgio Bruzadelli, de Souza, Melissa Paoletti, Guimarães, Ana Tereza Bittencourt, de Souza Figueiredo, Paulo Tadeu
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animal model Animals Bisphosphonate-Associated Osteonecrosis of the Jaw - diagnostic imaging Bisphosphonate-Associated Osteonecrosis of the Jaw - pathology Dentistry Diphosphonates - toxicity Disease Models, Animal Imidazoles - toxicity Longitudinal Studies Medication-related osteonecrosis of the jaws Microcomputed tomography Molar - diagnostic imaging Molar - surgery Rats Tooth Extraction X-Ray Microtomography Zoledronic acid
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Beschreibung
Zusammenfassung:	Highlights • This animal study design was successful in inducing MRONJ. • Tb.Th and BV/TV should be further investigated as potential early bone markers of MRONJ. • Bony changes were detected before the dental extraction in the ZA group.
ISSN:	0003-9969 1879-1506
DOI:	10.1016/j.archoralbio.2017.06.002