Reply: Directly Observed Therapy: A Possible Tool to Tackle Medication Nonadherence in the CVD Epidemic

[...]the circumstances in which DOT may be applied include local ambulatory care where patients have ready access to a clinic and can take their medications at a single point in time. Multiple adherence-building techniques, including reminder letters, lay health workers, monetary incentives, and increased supervision, have not demonstrated consistent, definitive efficacy in combating nonadherence. [...]research is clearly needed to assess any intervention to measure performance and acceptability for increasing adherence across different settings. 1 K.C...