Intravenous lacosamide in status epilepticus: Correlation between loading dose, serum levels, and clinical response

Highlights • LCM lacks a defined target serum levels after loading dose in SE. • A loading dose of >9 mg/kg is associated with serum levels above 10 mg/l. • Higher serum levels are not correlated with better clinical response in SE.

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Bibliographische Detailangaben
Veröffentlicht in:	Epilepsy research 2017-09, Vol.135, p.38-42
Hauptverfasser:	Perrenoud, Matthieu, André, Pascal, Alvarez, Vincent, Stähli, Christine, Decosterd, Laurent A, Rossetti, Andrea O, Novy, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides - administration & dosage Acetamides - blood Administration, Intravenous Adult Aged Aged, 80 and over Anticonvulsants - administration & dosage Anticonvulsants - blood Critical care Dose-Response Relationship, Drug Female Humans Male Middle Aged Neurology Outcome Retrospective Retrospective Studies Status Epilepticus - blood Status Epilepticus - drug therapy Status Epilepticus - mortality Therapeutic drug monitoring Treatment Outcome
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Beschreibung
Zusammenfassung:	Highlights • LCM lacks a defined target serum levels after loading dose in SE. • A loading dose of >9 mg/kg is associated with serum levels above 10 mg/l. • Higher serum levels are not correlated with better clinical response in SE.
ISSN:	0920-1211 1872-6844
DOI:	10.1016/j.eplepsyres.2017.05.007