Cafestol, a diterpene molecule found in coffee, induces leukemia cell death
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| Veröffentlicht in: | Biomedicine & pharmacotherapy 2017-08, Vol.92, p.1045-1054 |
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| container_title | Biomedicine & pharmacotherapy |
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| creator | Lima, Cauê S Spindola, Daniel G Bechara, Alexandre Garcia, Daniel M Palmeira-dos-Santos, Caroline Peixoto-da-Silva, Janaina Erustes, Adolfo G Michelin, Luis F.G Pereira, Gustavo J.S Smaili, Soraya S Paredes-Gamero, Edgar Calgarotto, Andrana K Oliveira, Carlos R Bincoletto, Claudia |
| description | Graphical abstract |
| doi_str_mv | 10.1016/j.biopha.2017.05.109 |
| format | Article |
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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-2fb4d2016d9d045604c99a184b49aa5ccd5d3b1b03c41a0115ed259a129fab3b3</citedby><cites>FETCH-LOGICAL-c417t-2fb4d2016d9d045604c99a184b49aa5ccd5d3b1b03c41a0115ed259a129fab3b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biopha.2017.05.109$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28618649$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lima, Cauê S</creatorcontrib><creatorcontrib>Spindola, Daniel G</creatorcontrib><creatorcontrib>Bechara, Alexandre</creatorcontrib><creatorcontrib>Garcia, Daniel M</creatorcontrib><creatorcontrib>Palmeira-dos-Santos, Caroline</creatorcontrib><creatorcontrib>Peixoto-da-Silva, Janaina</creatorcontrib><creatorcontrib>Erustes, Adolfo G</creatorcontrib><creatorcontrib>Michelin, Luis F.G</creatorcontrib><creatorcontrib>Pereira, Gustavo J.S</creatorcontrib><creatorcontrib>Smaili, Soraya S</creatorcontrib><creatorcontrib>Paredes-Gamero, Edgar</creatorcontrib><creatorcontrib>Calgarotto, Andrana K</creatorcontrib><creatorcontrib>Oliveira, Carlos R</creatorcontrib><creatorcontrib>Bincoletto, Claudia</creatorcontrib><title>Cafestol, a diterpene molecule found in coffee, induces leukemia cell death</title><title>Biomedicine & pharmacotherapy</title><addtitle>Biomed Pharmacother</addtitle><description>Graphical abstract</description><subject>Animals</subject><subject>Antimetabolites, Antineoplastic - pharmacology</subject><subject>Antineoplastic Agents, Phytogenic - isolation & purification</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Cafestol</subject><subject>Caspase 3 - metabolism</subject><subject>CD11b Antigen - metabolism</subject><subject>Cell Cycle Checkpoints - drug effects</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Clonogenicity</subject><subject>Coffea - chemistry</subject><subject>Cytarabine - pharmacology</subject><subject>Cytotoxicity</subject><subject>Diterpenes - isolation & purification</subject><subject>Diterpenes - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fucosyltransferases - metabolism</subject><subject>Hematopoietic Stem Cells - drug effects</subject><subject>Hematopoietic Stem Cells - metabolism</subject><subject>Hematopoietic Stem Cells - pathology</subject><subject>HL-60 Cells</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>K562 Cells</subject><subject>Leukemia</subject><subject>Leukemia - drug therapy</subject><subject>Leukemia - metabolism</subject><subject>Leukemia - pathology</subject><subject>Lewis X Antigen - metabolism</subject><subject>Male</subject><subject>Medical Education</subject><subject>Membrane Potential, Mitochondrial - drug effects</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Phosphatidylserines - metabolism</subject><subject>Phytotherapy</subject><subject>Plants, Medicinal</subject><subject>Reactive Oxygen Species - metabolism</subject><issn>0753-3322</issn><issn>1950-6007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vFDEMhiMEokvbf4BQjhw6i_M1s7kgoVVLEZU4AOcok3jUbDOTJZlB6r8noy0cuPRky3psv35NyFsGWwas_XDY9iEd7-2WA-u2oGpVvyAbphU0LUD3kmygU6IRgvMz8qaUAwCoVuxekzO-a9mulXpDvu7tgGVO8Ypa6sOM-YgT0jFFdEtEOqRl8jRM1KVhQLyqqV8cFhpxecAxWOowRurRzvcX5NVgY8HLp3hOft5c_9jfNnffPn_Zf7prnGTd3PChl76Kbr32IFUL0mlt2U72UlurnPPKi571ICpvgTGFnqtKcD3YXvTinLw_zT3m9Gup6s0YyirDTpiWYphm0GklNVRUnlCXUykZB3PMYbT50TAwq43mYE42mtVGA6pWdW1797Rh6Uf0_5r--laBjycA652_A2ZTXMDJoQ8Z3Wx8Cs9t-H-Ai2EKzsYHfMRySEueqoeGmcINmO_rK9dPsk4wztpO_AHFIJlX</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Lima, Cauê S</creator><creator>Spindola, Daniel G</creator><creator>Bechara, Alexandre</creator><creator>Garcia, Daniel M</creator><creator>Palmeira-dos-Santos, Caroline</creator><creator>Peixoto-da-Silva, Janaina</creator><creator>Erustes, Adolfo G</creator><creator>Michelin, Luis F.G</creator><creator>Pereira, Gustavo J.S</creator><creator>Smaili, Soraya S</creator><creator>Paredes-Gamero, Edgar</creator><creator>Calgarotto, Andrana K</creator><creator>Oliveira, Carlos R</creator><creator>Bincoletto, Claudia</creator><general>Elsevier Masson SAS</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170801</creationdate><title>Cafestol, a diterpene molecule found in coffee, induces leukemia cell death</title><author>Lima, Cauê S ; Spindola, Daniel G ; Bechara, Alexandre ; Garcia, Daniel M ; Palmeira-dos-Santos, Caroline ; Peixoto-da-Silva, Janaina ; Erustes, Adolfo G ; Michelin, Luis F.G ; Pereira, Gustavo J.S ; Smaili, Soraya S ; Paredes-Gamero, Edgar ; Calgarotto, Andrana K ; Oliveira, Carlos R ; Bincoletto, Claudia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-2fb4d2016d9d045604c99a184b49aa5ccd5d3b1b03c41a0115ed259a129fab3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Antimetabolites, Antineoplastic - pharmacology</topic><topic>Antineoplastic Agents, Phytogenic - isolation & purification</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Cafestol</topic><topic>Caspase 3 - metabolism</topic><topic>CD11b Antigen - metabolism</topic><topic>Cell Cycle Checkpoints - drug effects</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Clonogenicity</topic><topic>Coffea - chemistry</topic><topic>Cytarabine - pharmacology</topic><topic>Cytotoxicity</topic><topic>Diterpenes - isolation & purification</topic><topic>Diterpenes - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fucosyltransferases - metabolism</topic><topic>Hematopoietic Stem Cells - drug effects</topic><topic>Hematopoietic Stem Cells - metabolism</topic><topic>Hematopoietic Stem Cells - pathology</topic><topic>HL-60 Cells</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>K562 Cells</topic><topic>Leukemia</topic><topic>Leukemia - 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| fulltext | fulltext |
| identifier | ISSN: 0753-3322 |
| ispartof | Biomedicine & pharmacotherapy, 2017-08, Vol.92, p.1045-1054 |
| issn | 0753-3322 1950-6007 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Antimetabolites, Antineoplastic - pharmacology Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Apoptosis - drug effects Cafestol Caspase 3 - metabolism CD11b Antigen - metabolism Cell Cycle Checkpoints - drug effects Cell Proliferation - drug effects Cell Survival - drug effects Clonogenicity Coffea - chemistry Cytarabine - pharmacology Cytotoxicity Diterpenes - isolation & purification Diterpenes - pharmacology Dose-Response Relationship, Drug Fucosyltransferases - metabolism Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - metabolism Hematopoietic Stem Cells - pathology HL-60 Cells Humans Internal Medicine K562 Cells Leukemia Leukemia - drug therapy Leukemia - metabolism Leukemia - pathology Lewis X Antigen - metabolism Male Medical Education Membrane Potential, Mitochondrial - drug effects Mice Mice, Inbred C57BL Phosphatidylserines - metabolism Phytotherapy Plants, Medicinal Reactive Oxygen Species - metabolism |
| title | Cafestol, a diterpene molecule found in coffee, induces leukemia cell death |
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