Cafestol, a diterpene molecule found in coffee, induces leukemia cell death

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Bibliographische Detailangaben
Veröffentlicht in:	Biomedicine & pharmacotherapy 2017-08, Vol.92, p.1045-1054
Hauptverfasser:	Lima, Cauê S, Spindola, Daniel G, Bechara, Alexandre, Garcia, Daniel M, Palmeira-dos-Santos, Caroline, Peixoto-da-Silva, Janaina, Erustes, Adolfo G, Michelin, Luis F.G, Pereira, Gustavo J.S, Smaili, Soraya S, Paredes-Gamero, Edgar, Calgarotto, Andrana K, Oliveira, Carlos R, Bincoletto, Claudia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimetabolites, Antineoplastic - pharmacology Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Apoptosis - drug effects Cafestol Caspase 3 - metabolism CD11b Antigen - metabolism Cell Cycle Checkpoints - drug effects Cell Proliferation - drug effects Cell Survival - drug effects Clonogenicity Coffea - chemistry Cytarabine - pharmacology Cytotoxicity Diterpenes - isolation & purification Diterpenes - pharmacology Dose-Response Relationship, Drug Fucosyltransferases - metabolism Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - metabolism Hematopoietic Stem Cells - pathology HL-60 Cells Humans Internal Medicine K562 Cells Leukemia Leukemia - drug therapy Leukemia - metabolism Leukemia - pathology Lewis X Antigen - metabolism Male Medical Education Membrane Potential, Mitochondrial - drug effects Mice Mice, Inbred C57BL Phosphatidylserines - metabolism Phytotherapy Plants, Medicinal Reactive Oxygen Species - metabolism
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Zusammenfassung:	Graphical abstract
ISSN:	0753-3322 1950-6007
DOI:	10.1016/j.biopha.2017.05.109