Comment on "Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing"

Comment on "Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing"

Chen (Reports, 28 October 2016, p. 468) proposed that an interaction between Xist RNA and Lamin B receptor (LBR) is necessary and sufficient for Xist spreading during X-chromosome inactivation. We reanalyzed their data and found that reported genotypes of mutants are not supported by the sequencing...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 2017-06, Vol.356 (6343)
Hauptverfasser: Wang, Chen-Yu, Froberg, John E, Blum, Roy, Jeon, Yesu, Lee, Jeannie T
Format: Artikel
Sprache:eng
Schlagworte:
Gene Silencing
Nuclear Lamina
RNA, Long Noncoding - genetics
RNA, Untranslated - genetics
X Chromosome
X Chromosome Inactivation
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Zusammenfassung:Chen (Reports, 28 October 2016, p. 468) proposed that an interaction between Xist RNA and Lamin B receptor (LBR) is necessary and sufficient for Xist spreading during X-chromosome inactivation. We reanalyzed their data and found that reported genotypes of mutants are not supported by the sequencing data. These inconsistencies preclude assessment of the role of LBR in Xist spreading.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.aal4976