A perfluorobutylpentane (F4H5)‐based solution for the removal of residual emulsified silicone oil

Purpose The emulsification of silicone oil (SO) is associated with many complications. In this study, we investigate a new SO solvent, perfluorobutylpentane (F4H5) with 1% by volume of perfluorinated polyethers–polyethylene glycol–perfluorinated polyethers (PFPE‐PEG‐PFPE) triblock copolymer, for removing emulsified droplets. Methods An in vitro 3D printed model eye chamber was used to evaluate the efficiency of the three test liquids in removing SO droplets, namely saline, F4H5 and F4H5 with surfactant PFPE‐PEG‐PFPE. The numbers of SO droplets were quantified using a Coulter Counter. The stability of double emulsion formed was tested with a fluidic device based on electro‐coalescence. Two retinal cell lines were used to test the biocompatibility of the liquids. Results The mean number of droplets remaining in the eye chamber after rinsing with a solution of F4H5 with surfactant was 13 315 ± 4620/ml compared to saline (23 460 ± 7595/ml; p