Age-specific profiling of cutaneous allergy at high temporal resolution suggests age-related alterations in regulatory immune function

Age-specific profiling of cutaneous allergy at high temporal resolution suggests age-related alterations in regulatory immune function

Summary We report the age-specific prevalence of cutaneous allergy in 45110 patients over a 30 year period. Our analysis reveals complex allergen-specific sensitization profiles which may reflect alterations in T-cell mediated immunity and regulatory immune function.

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Bibliographische Detailangaben
Veröffentlicht in:Journal of allergy and clinical immunology 2017-11, Vol.140 (5), p.1451-1453.e5
Hauptverfasser: Lynch, Magnus David, MA DPhil MRCP, McFadden, John Paul, DM FRCP, White, Jonathan Michael, MRCP, Banerjee, Piu, MD FRCP, White, Ian Richard, FRCP FFOM FRSC
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Age
Aged
Aged, 80 and over
Aging - immunology
Allergens - adverse effects
Allergies
Allergy and Immunology
Child
Child, Preschool
Dermatitis
Female
Humans
Hypersensitivity - diagnosis
Hypersensitivity - epidemiology
Hypersensitivity - immunology
Immune response
Infant
Infant, Newborn
Male
Middle Aged
Older people
Patch Tests
Patients
Skin - immunology
Temporal resolution
Young Adult
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Zusammenfassung:Summary We report the age-specific prevalence of cutaneous allergy in 45110 patients over a 30 year period. Our analysis reveals complex allergen-specific sensitization profiles which may reflect alterations in T-cell mediated immunity and regulatory immune function.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.03.054