Effect of dietary fatty acid and micronutrient intake/energy ratio on serum diamine oxidase activity in healthy women

Abstract Objective Serum diamine oxidase (DAO) activity varies to a greater extent in women than in men. DAO activity during the luteal phase was higher than that during the follicular phase in healthy women. Recent reports have indicated that duodenal lipid infusion increased DAO activity in the intestinal lymph in rats. The purpose of this study was to elucidate the effect of dietary nutrient intake on serum DAO activity in healthy women. Research Methods and Procedures Thirty-four healthy Japanese women were recruited. Food surveys were performed using dietary records for 3 days during both the follicular and luteal phases. Nutrient intake was calculated and expressed as the energy intake ratio. The correlation between DAO activity and nutrient intake was analyzed. Results Serum DAO activity in both phases was positively correlated with long chain fatty acid, saturated fatty acid, and monounsaturated fatty acid intakes ( p < 0.05). Phosphorus, calcium, zinc, magnesium, iron, and vitamin B12 intakes during the luteal phase were positively correlated with serum DAO activity ( p < 0.05). Conclusion In healthy women, serum DAO activity was influenced by dietary fatty acid and micronutrient intake.