Current and future therapies for advanced pancreatic cancer

Pancreatic cancer remains a deadly disease with a 5‐year survival rate of only 8%. Even after surgical resection, most patients have recurrence of their cancer. Over the last 10 years, improvements in chemotherapy regimens led to a doubling in median overall survival. Here we review the management o...

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Veröffentlicht in:	Journal of surgical oncology 2017-07, Vol.116 (1), p.25-34
Hauptverfasser:	Gupta, Rohan, Amanam, Idoroenyi, Chung, Vincent
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - analysis CA-19-9 Antigen - analysis Cancer Pain - therapy Cancer surgery Cancer therapies Chemotherapy, Adjuvant Clinical Trials as Topic cytotoxic chemotherapy Genetic Predisposition to Disease Humans Neoadjuvant Therapy Neoplasm Staging pancreas cancer Pancreatic cancer Pancreatic Neoplasms - diagnosis Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Pancreatic Neoplasms - therapy Risk Factors vaccine therapy
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Beschreibung
Zusammenfassung:	Pancreatic cancer remains a deadly disease with a 5‐year survival rate of only 8%. Even after surgical resection, most patients have recurrence of their cancer. Over the last 10 years, improvements in chemotherapy regimens led to a doubling in median overall survival. Here we review the management of advanced pancreatic cancer and highlight vaccine therapy as a novel modality of treatment.
ISSN:	0022-4790 1096-9098
DOI:	10.1002/jso.24623