Identification and characterization of new members of the SXT/R391 family of integrative and conjugative elements (ICEs) in Proteus mirabilis

Highlights • Three new SXT/R391 family integrative and conjugative elements (ICEs) were identified in Proteus mirabilis. • The roles of ICEs in antimicrobial resistance were shown by structural analysis. • ICE Pmi Chn3 has a unique structure that lacks core conjugation genes. • The roles of the miss...

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Veröffentlicht in:	International journal of antimicrobial agents 2017-08, Vol.50 (2), p.242-246
Hauptverfasser:	Bie, Luyao, Wu, Hao, Wang, Xin-Hua, Wang, Mingyu, Xu, Hai
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - metabolism Antimicrobial resistance China Conjugation cassette Conjugation, Genetic Drug Resistance, Multiple, Bacterial Evolution, Molecular Gene Order Gene Transfer, Horizontal Infectious Disease Integrative and conjugative elements Interspersed Repetitive Sequences Microbial Sensitivity Tests Mobile genetic elements Phylogeny Proteus mirabilis Proteus mirabilis - drug effects Proteus mirabilis - genetics SXT/R391 family Trimethoprim, Sulfamethoxazole Drug Combination - metabolism
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Zusammenfassung:	Highlights • Three new SXT/R391 family integrative and conjugative elements (ICEs) were identified in Proteus mirabilis. • The roles of ICEs in antimicrobial resistance were shown by structural analysis. • ICE Pmi Chn3 has a unique structure that lacks core conjugation genes. • The roles of the missing genes in conjugation were confirmed. • ICE Pmi Chn3 evolves from a mobile ICE ancestor shared by other ICEs found in China.
ISSN:	0924-8579 1872-7913
DOI:	10.1016/j.ijantimicag.2017.01.045