Comment on: “Assessing Pruritus in Hidradenitis Suppurativa: A Cross-Sectional Study”

[...]an increasing number of publications on this topic may help us to manage this relevant symptom in HS patients. [...]in our opinion, the alteration in the mammalian target of rapamycin (mTOR) signalling may also contribute to, or may even be the key element for, the pathogenic mechanisms leading to itch in HS. mTOR belongs to the phosphatidylinositol 3-kinase-related kinase protein family and forms at least two multiprotein complexes known as mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2) [5]. mTOR is a major regulator of survival, growth, proliferation and motility, in response to mitogens, energy and nutrient levels [6]. Due to its central role in cellular functions, mTOR dysregulation is involved in a number of inflammatory or neoplastic conditions. [...]mTOR activities are also reported to be altered in metabolic and autoimmune disorders [7]. mTOR involvement in some of the most common inflammatory dermatoses, such as psoriasis, acne, and HS, has recently been demonstrated [8-10]. In particular, mTOR has been found to be increased in lesional as well as non-lesional skin of HS patients [10]. [...]mTOR gene expression statistically correlates with the severity of HS [10].