Expressions of MACC1, Snail, and KISS-1 Proteins in Infiltrating Breast Carcinoma and Its Clinicopathological Features

To investigate the protein expressions of metastasis-associated in colon cancer 1 (MACC1), KISS-1 (a cancer ruppressor gene) and Snail (the marker of epithelial-mesenchymal transition) in infiltrating breast carcinoma (IBC) and explore the role of them in invasion, metastasis and prognosis in IBC. E...

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Veröffentlicht in:	Sichuan da xue xue bao. Journal of Sichuan University. Yi xue ban 2016-09, Vol.47 (5), p.732-737
Hauptverfasser:	Dong, Hui-Ming, Huang, Jian-Kang, Gong, Xiao-Meng, Tao, Yi-Sheng
Format:	Artikel
Sprache:	chi
Schlagworte:	Breast Neoplasms - diagnosis Breast Neoplasms - metabolism Humans Kisspeptins - metabolism Lymphatic Metastasis Prognosis Snail Family Transcription Factors - metabolism Transcription Factors - metabolism
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Zusammenfassung:	To investigate the protein expressions of metastasis-associated in colon cancer 1 (MACC1), KISS-1 (a cancer ruppressor gene) and Snail (the marker of epithelial-mesenchymal transition) in infiltrating breast carcinoma (IBC) and explore the role of them in invasion, metastasis and prognosis in IBC. Expressions of MACC1, Snail and KISS-1 were examined by immunohistochemistry in 250 specimens of IBC and 80 specimens of normal breast tissues. Their clinicopathological features were analyzed, and their influence on patients' survival was identified. The positive rate of MACC1, Snail and KISS-1 in normal breast tissues and IBC tissues was 7.5%, 5.0%, 87.5% and 63.6%, 58.8%, 38.0%, respectively. And there was a significant difference between the IBC group and control group (
ISSN:	1672-173X