Influence of two variants of CYP450 oxidoreductase on the stable dose of acenocoumarol in a Spanish population

To evaluate the influence of two variants of P450 oxidoreductase (POR), rs2868177 and , on the stable dosage of acenocoumarol. For this observational, cross-sectional study, patients were undergone stable anticoagulant treatment with acenocoumarol. Univariate and multiple regression analyses were performed to assess the influence of polymorphisms. About 340 patients were enrolled. Multiple regression had a coefficient of determination (R ) of 51.5% and an Akaike information criterion of 234.22. The inclusion of polymorphisms increased the R to 52.0% and reduced the Akaike information criteria to 230.58. The heterozygote showed statistical significance in the algorithm. The heterozygote appears to be associated with the stable dose of acenocoumarol, but its clinical contribution to the prediction of the dosing of this drug is minimal.