Association of the IL6 rs1800796, but not of the IL6 rs1800795, IL6R rs4845617 and rs2228145 polymorphisms with hip fracture in elderly Mexican women
Background and aims Polymorphisms in Interleukin-6 ( IL6 ) and its receptor ( IL6R ) have been associated with bone mineral density. In this work, the G-174C and G-572C polymorphisms in IL6 , G-208A, and Asp358Ala in IL6R were analyzed in Mexican women with hip fracture. Methods Postmenopausal Mexic...
Gespeichert in:
| Veröffentlicht in: | Aging clinical and experimental research 2018-04, Vol.30 (4), p.407-410 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 410 |
|---|---|
| container_issue | 4 |
| container_start_page | 407 |
| container_title | Aging clinical and experimental research |
| container_volume | 30 |
| creator | Ponce de León-Suárez, Valeria Valdés-Flores, Margarita Miranda-Duarte, Antonio Ramírez-Pérez, Esperanza Pérez-Ríos, Alin Barredo-Prieto, Blanca Hidalgo-Bravo, Alberto Casas-Avila, Leonora |
| description | Background and aims
Polymorphisms in Interleukin-6 (
IL6
) and its receptor (
IL6R
) have been associated with bone mineral density. In this work, the G-174C and G-572C polymorphisms in
IL6
, G-208A, and Asp358Ala in
IL6R
were analyzed in Mexican women with hip fracture.
Methods
Postmenopausal Mexican women (60 years or over) with hip fragility fracture (77.97 ± 8 years) and without hip fracture (70.5 ± 7.02 years) were genotyped by real-time PCR.
Results
The rs1800796 GG genotype was associated with low risk of fracture (
p
= 0.05), while GC genotype was associated with high risk of fracture [
p
= 0.047, OR 2.3 (95% CI 1.013–5.2)]. The AA genotype of the rs2228145 SNP (
IL6R
) was significantly different [
p
= 0.033, OR 1.94 (95% CI 1.01–3.75)], but when data were adjusted by age and body mass index, there were no differences (
p
= 0.9).
Conclusion
Our results suggest that the
IL6
rs1800796 SNP is a good marker for hip fracture risk in Mexican women. |
| doi_str_mv | 10.1007/s40520-017-0779-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1907320386</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1907320386</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-c5e7d47e4ef72a98db6cfbd18f46afdde0dd916ec39732bdb2d98c43970261f53</originalsourceid><addsrcrecordid>eNp1kdtqFTEYhYMotlYfwBsJeNOLjuY0OVyWYrWwS6Hodcjk4E6ZScZkhrofxPc1m10PSL1KVv5vrT-wAHiN0TuMkHhfGeoJ6hAWHRJCdeIJOMaivUiK1dO_7kfgRa13CDHcxHNwRGSvKOPyGPw4rzXbaJaYE8wBLlsPrzYcloplW6H4GRzWBaa8PDbtz_bytmkmWc-xgCa5pgghErMeznncTbnM21inCu_jsoXbOMNQjF3W4mFM0I_Ol3EHr_33aE2C93ny6SV4FsxY_auH8wR8ufzw-eJTt7n5eHVxvuksFWTpbO-FY8IzHwQxSrqB2zA4LAPjJjjnkXMKc2-pEpQMbiBOScuaQoTj0NMTcHrInUv-tvq66ClW68fRJJ_XqrFCzYio5A19-w96l9eS2u80oUxh3EuqGoUPlC251uKDnkucTNlpjPS-M33oTLfO9L4zLZrnzUPyOkze_Xb8KqkB5ADUNkpfffmz-v-pPwHnu51M</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2349115839</pqid></control><display><type>article</type><title>Association of the IL6 rs1800796, but not of the IL6 rs1800795, IL6R rs4845617 and rs2228145 polymorphisms with hip fracture in elderly Mexican women</title><source>Springer Online Journals Complete</source><creator>Ponce de León-Suárez, Valeria ; Valdés-Flores, Margarita ; Miranda-Duarte, Antonio ; Ramírez-Pérez, Esperanza ; Pérez-Ríos, Alin ; Barredo-Prieto, Blanca ; Hidalgo-Bravo, Alberto ; Casas-Avila, Leonora</creator><creatorcontrib>Ponce de León-Suárez, Valeria ; Valdés-Flores, Margarita ; Miranda-Duarte, Antonio ; Ramírez-Pérez, Esperanza ; Pérez-Ríos, Alin ; Barredo-Prieto, Blanca ; Hidalgo-Bravo, Alberto ; Casas-Avila, Leonora</creatorcontrib><description>Background and aims
Polymorphisms in Interleukin-6 (
IL6
) and its receptor (
IL6R
) have been associated with bone mineral density. In this work, the G-174C and G-572C polymorphisms in
IL6
, G-208A, and Asp358Ala in
IL6R
were analyzed in Mexican women with hip fracture.
Methods
Postmenopausal Mexican women (60 years or over) with hip fragility fracture (77.97 ± 8 years) and without hip fracture (70.5 ± 7.02 years) were genotyped by real-time PCR.
Results
The rs1800796 GG genotype was associated with low risk of fracture (
p
= 0.05), while GC genotype was associated with high risk of fracture [
p
= 0.047, OR 2.3 (95% CI 1.013–5.2)]. The AA genotype of the rs2228145 SNP (
IL6R
) was significantly different [
p
= 0.033, OR 1.94 (95% CI 1.01–3.75)], but when data were adjusted by age and body mass index, there were no differences (
p
= 0.9).
Conclusion
Our results suggest that the
IL6
rs1800796 SNP is a good marker for hip fracture risk in Mexican women.</description><identifier>ISSN: 1720-8319</identifier><identifier>ISSN: 1594-0667</identifier><identifier>EISSN: 1720-8319</identifier><identifier>DOI: 10.1007/s40520-017-0779-7</identifier><identifier>PMID: 28593468</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Fractures ; Genotype & phenotype ; Geriatrics/Gerontology ; Health risk assessment ; Medicine ; Medicine & Public Health ; Short Communication</subject><ispartof>Aging clinical and experimental research, 2018-04, Vol.30 (4), p.407-410</ispartof><rights>Springer International Publishing Switzerland 2017</rights><rights>Aging Clinical and Experimental Research is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-c5e7d47e4ef72a98db6cfbd18f46afdde0dd916ec39732bdb2d98c43970261f53</citedby><cites>FETCH-LOGICAL-c372t-c5e7d47e4ef72a98db6cfbd18f46afdde0dd916ec39732bdb2d98c43970261f53</cites><orcidid>0000-0001-6238-4538</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40520-017-0779-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40520-017-0779-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28593468$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ponce de León-Suárez, Valeria</creatorcontrib><creatorcontrib>Valdés-Flores, Margarita</creatorcontrib><creatorcontrib>Miranda-Duarte, Antonio</creatorcontrib><creatorcontrib>Ramírez-Pérez, Esperanza</creatorcontrib><creatorcontrib>Pérez-Ríos, Alin</creatorcontrib><creatorcontrib>Barredo-Prieto, Blanca</creatorcontrib><creatorcontrib>Hidalgo-Bravo, Alberto</creatorcontrib><creatorcontrib>Casas-Avila, Leonora</creatorcontrib><title>Association of the IL6 rs1800796, but not of the IL6 rs1800795, IL6R rs4845617 and rs2228145 polymorphisms with hip fracture in elderly Mexican women</title><title>Aging clinical and experimental research</title><addtitle>Aging Clin Exp Res</addtitle><addtitle>Aging Clin Exp Res</addtitle><description>Background and aims
Polymorphisms in Interleukin-6 (
IL6
) and its receptor (
IL6R
) have been associated with bone mineral density. In this work, the G-174C and G-572C polymorphisms in
IL6
, G-208A, and Asp358Ala in
IL6R
were analyzed in Mexican women with hip fracture.
Methods
Postmenopausal Mexican women (60 years or over) with hip fragility fracture (77.97 ± 8 years) and without hip fracture (70.5 ± 7.02 years) were genotyped by real-time PCR.
Results
The rs1800796 GG genotype was associated with low risk of fracture (
p
= 0.05), while GC genotype was associated with high risk of fracture [
p
= 0.047, OR 2.3 (95% CI 1.013–5.2)]. The AA genotype of the rs2228145 SNP (
IL6R
) was significantly different [
p
= 0.033, OR 1.94 (95% CI 1.01–3.75)], but when data were adjusted by age and body mass index, there were no differences (
p
= 0.9).
Conclusion
Our results suggest that the
IL6
rs1800796 SNP is a good marker for hip fracture risk in Mexican women.</description><subject>Fractures</subject><subject>Genotype & phenotype</subject><subject>Geriatrics/Gerontology</subject><subject>Health risk assessment</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Short Communication</subject><issn>1720-8319</issn><issn>1594-0667</issn><issn>1720-8319</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kdtqFTEYhYMotlYfwBsJeNOLjuY0OVyWYrWwS6Hodcjk4E6ZScZkhrofxPc1m10PSL1KVv5vrT-wAHiN0TuMkHhfGeoJ6hAWHRJCdeIJOMaivUiK1dO_7kfgRa13CDHcxHNwRGSvKOPyGPw4rzXbaJaYE8wBLlsPrzYcloplW6H4GRzWBaa8PDbtz_bytmkmWc-xgCa5pgghErMeznncTbnM21inCu_jsoXbOMNQjF3W4mFM0I_Ol3EHr_33aE2C93ny6SV4FsxY_auH8wR8ufzw-eJTt7n5eHVxvuksFWTpbO-FY8IzHwQxSrqB2zA4LAPjJjjnkXMKc2-pEpQMbiBOScuaQoTj0NMTcHrInUv-tvq66ClW68fRJJ_XqrFCzYio5A19-w96l9eS2u80oUxh3EuqGoUPlC251uKDnkucTNlpjPS-M33oTLfO9L4zLZrnzUPyOkze_Xb8KqkB5ADUNkpfffmz-v-pPwHnu51M</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Ponce de León-Suárez, Valeria</creator><creator>Valdés-Flores, Margarita</creator><creator>Miranda-Duarte, Antonio</creator><creator>Ramírez-Pérez, Esperanza</creator><creator>Pérez-Ríos, Alin</creator><creator>Barredo-Prieto, Blanca</creator><creator>Hidalgo-Bravo, Alberto</creator><creator>Casas-Avila, Leonora</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6238-4538</orcidid></search><sort><creationdate>20180401</creationdate><title>Association of the IL6 rs1800796, but not of the IL6 rs1800795, IL6R rs4845617 and rs2228145 polymorphisms with hip fracture in elderly Mexican women</title><author>Ponce de León-Suárez, Valeria ; Valdés-Flores, Margarita ; Miranda-Duarte, Antonio ; Ramírez-Pérez, Esperanza ; Pérez-Ríos, Alin ; Barredo-Prieto, Blanca ; Hidalgo-Bravo, Alberto ; Casas-Avila, Leonora</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-c5e7d47e4ef72a98db6cfbd18f46afdde0dd916ec39732bdb2d98c43970261f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Fractures</topic><topic>Genotype & phenotype</topic><topic>Geriatrics/Gerontology</topic><topic>Health risk assessment</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Short Communication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ponce de León-Suárez, Valeria</creatorcontrib><creatorcontrib>Valdés-Flores, Margarita</creatorcontrib><creatorcontrib>Miranda-Duarte, Antonio</creatorcontrib><creatorcontrib>Ramírez-Pérez, Esperanza</creatorcontrib><creatorcontrib>Pérez-Ríos, Alin</creatorcontrib><creatorcontrib>Barredo-Prieto, Blanca</creatorcontrib><creatorcontrib>Hidalgo-Bravo, Alberto</creatorcontrib><creatorcontrib>Casas-Avila, Leonora</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Aging clinical and experimental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ponce de León-Suárez, Valeria</au><au>Valdés-Flores, Margarita</au><au>Miranda-Duarte, Antonio</au><au>Ramírez-Pérez, Esperanza</au><au>Pérez-Ríos, Alin</au><au>Barredo-Prieto, Blanca</au><au>Hidalgo-Bravo, Alberto</au><au>Casas-Avila, Leonora</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of the IL6 rs1800796, but not of the IL6 rs1800795, IL6R rs4845617 and rs2228145 polymorphisms with hip fracture in elderly Mexican women</atitle><jtitle>Aging clinical and experimental research</jtitle><stitle>Aging Clin Exp Res</stitle><addtitle>Aging Clin Exp Res</addtitle><date>2018-04-01</date><risdate>2018</risdate><volume>30</volume><issue>4</issue><spage>407</spage><epage>410</epage><pages>407-410</pages><issn>1720-8319</issn><issn>1594-0667</issn><eissn>1720-8319</eissn><abstract>Background and aims
Polymorphisms in Interleukin-6 (
IL6
) and its receptor (
IL6R
) have been associated with bone mineral density. In this work, the G-174C and G-572C polymorphisms in
IL6
, G-208A, and Asp358Ala in
IL6R
were analyzed in Mexican women with hip fracture.
Methods
Postmenopausal Mexican women (60 years or over) with hip fragility fracture (77.97 ± 8 years) and without hip fracture (70.5 ± 7.02 years) were genotyped by real-time PCR.
Results
The rs1800796 GG genotype was associated with low risk of fracture (
p
= 0.05), while GC genotype was associated with high risk of fracture [
p
= 0.047, OR 2.3 (95% CI 1.013–5.2)]. The AA genotype of the rs2228145 SNP (
IL6R
) was significantly different [
p
= 0.033, OR 1.94 (95% CI 1.01–3.75)], but when data were adjusted by age and body mass index, there were no differences (
p
= 0.9).
Conclusion
Our results suggest that the
IL6
rs1800796 SNP is a good marker for hip fracture risk in Mexican women.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>28593468</pmid><doi>10.1007/s40520-017-0779-7</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0001-6238-4538</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1720-8319 |
| ispartof | Aging clinical and experimental research, 2018-04, Vol.30 (4), p.407-410 |
| issn | 1720-8319 1594-0667 1720-8319 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1907320386 |
| source | Springer Online Journals Complete |
| subjects | Fractures Genotype & phenotype Geriatrics/Gerontology Health risk assessment Medicine Medicine & Public Health Short Communication |
| title | Association of the IL6 rs1800796, but not of the IL6 rs1800795, IL6R rs4845617 and rs2228145 polymorphisms with hip fracture in elderly Mexican women |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T17%3A35%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20the%20IL6%20rs1800796,%20but%20not%20of%20the%20IL6%20rs1800795,%20IL6R%20rs4845617%20and%20rs2228145%20polymorphisms%20with%20hip%20fracture%20in%20elderly%20Mexican%20women&rft.jtitle=Aging%20clinical%20and%20experimental%20research&rft.au=Ponce%20de%20Le%C3%B3n-Su%C3%A1rez,%20Valeria&rft.date=2018-04-01&rft.volume=30&rft.issue=4&rft.spage=407&rft.epage=410&rft.pages=407-410&rft.issn=1720-8319&rft.eissn=1720-8319&rft_id=info:doi/10.1007/s40520-017-0779-7&rft_dat=%3Cproquest_cross%3E1907320386%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2349115839&rft_id=info:pmid/28593468&rfr_iscdi=true |