Association of the IL6 rs1800796, but not of the IL6 rs1800795, IL6R rs4845617 and rs2228145 polymorphisms with hip fracture in elderly Mexican women

Background and aims Polymorphisms in Interleukin-6 ( IL6 ) and its receptor ( IL6R ) have been associated with bone mineral density. In this work, the G-174C and G-572C polymorphisms in IL6 , G-208A, and Asp358Ala in IL6R were analyzed in Mexican women with hip fracture. Methods Postmenopausal Mexican women (60 years or over) with hip fragility fracture (77.97 ± 8 years) and without hip fracture (70.5 ± 7.02 years) were genotyped by real-time PCR. Results The rs1800796 GG genotype was associated with low risk of fracture ( p = 0.05), while GC genotype was associated with high risk of fracture [ p = 0.047, OR 2.3 (95% CI 1.013–5.2)]. The AA genotype of the rs2228145 SNP ( IL6R ) was significantly different [ p = 0.033, OR 1.94 (95% CI 1.01–3.75)], but when data were adjusted by age and body mass index, there were no differences ( p = 0.9). Conclusion Our results suggest that the IL6 rs1800796 SNP is a good marker for hip fracture risk in Mexican women.