DOSY Analysis of Micromolar Analytes: Resolving Dilute Mixtures by SABRE Hyperpolarization
DOSY is an NMR spectroscopy technique that resolves resonances according to the analytes’ diffusion coefficients. It has found use in correlating NMR signals and estimating the number of components in mixtures. Applications of DOSY in dilute mixtures are, however, held back by excessively long measu...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2017-07, Vol.56 (31), p.9174-9177 |
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| container_title | Angewandte Chemie International Edition |
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| creator | Reile, Indrek Aspers, Ruud L. E. G. Tyburn, Jean‐Max Kempf, James G. Feiters, Martin C. Rutjes, Floris P. J. T. Tessari, Marco |
| description | DOSY is an NMR spectroscopy technique that resolves resonances according to the analytes’ diffusion coefficients. It has found use in correlating NMR signals and estimating the number of components in mixtures. Applications of DOSY in dilute mixtures are, however, held back by excessively long measurement times. We demonstrate herein, how the enhanced NMR sensitivity provided by SABRE hyperpolarization allows DOSY analysis of low‐micromolar mixtures, thus reducing the concentration requirements by at least 100‐fold.
How low can DOSY go? DOSY analysis of a low‐micromolar mixture is achieved by combining DOSY with nuclear spin hyperpolarization. SABRE hyperpolarization enhances NMR signals by two orders of magnitude, resolving six dilute analytes in a 35 min SABRE‐DOSY experiment. |
| doi_str_mv | 10.1002/anie.201703577 |
| format | Article |
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How low can DOSY go? DOSY analysis of a low‐micromolar mixture is achieved by combining DOSY with nuclear spin hyperpolarization. SABRE hyperpolarization enhances NMR signals by two orders of magnitude, resolving six dilute analytes in a 35 min SABRE‐DOSY experiment.</description><edition>International ed. in English</edition><identifier>ISSN: 1433-7851</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.201703577</identifier><identifier>PMID: 28590559</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Dilution ; DOSY ; Hyperpolarization ; Magnetic resonance spectroscopy ; NMR spectroscopy ; parahydrogen ; SABRE ; Sensitivity analysis ; Sensitivity enhancement ; Spectroscopic analysis</subject><ispartof>Angewandte Chemie International Edition, 2017-07, Vol.56 (31), p.9174-9177</ispartof><rights>2017 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4507-3abb590a4d7220898be792114185a18ad208fc0227baefc3edfbdd1248aa68ba3</citedby><cites>FETCH-LOGICAL-c4507-3abb590a4d7220898be792114185a18ad208fc0227baefc3edfbdd1248aa68ba3</cites><orcidid>0000-0001-8793-0072</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fanie.201703577$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fanie.201703577$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28590559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reile, Indrek</creatorcontrib><creatorcontrib>Aspers, Ruud L. E. G.</creatorcontrib><creatorcontrib>Tyburn, Jean‐Max</creatorcontrib><creatorcontrib>Kempf, James G.</creatorcontrib><creatorcontrib>Feiters, Martin C.</creatorcontrib><creatorcontrib>Rutjes, Floris P. J. T.</creatorcontrib><creatorcontrib>Tessari, Marco</creatorcontrib><title>DOSY Analysis of Micromolar Analytes: Resolving Dilute Mixtures by SABRE Hyperpolarization</title><title>Angewandte Chemie International Edition</title><addtitle>Angew Chem Int Ed Engl</addtitle><description>DOSY is an NMR spectroscopy technique that resolves resonances according to the analytes’ diffusion coefficients. It has found use in correlating NMR signals and estimating the number of components in mixtures. Applications of DOSY in dilute mixtures are, however, held back by excessively long measurement times. We demonstrate herein, how the enhanced NMR sensitivity provided by SABRE hyperpolarization allows DOSY analysis of low‐micromolar mixtures, thus reducing the concentration requirements by at least 100‐fold.
How low can DOSY go? DOSY analysis of a low‐micromolar mixture is achieved by combining DOSY with nuclear spin hyperpolarization. SABRE hyperpolarization enhances NMR signals by two orders of magnitude, resolving six dilute analytes in a 35 min SABRE‐DOSY experiment.</description><subject>Dilution</subject><subject>DOSY</subject><subject>Hyperpolarization</subject><subject>Magnetic resonance spectroscopy</subject><subject>NMR spectroscopy</subject><subject>parahydrogen</subject><subject>SABRE</subject><subject>Sensitivity analysis</subject><subject>Sensitivity enhancement</subject><subject>Spectroscopic analysis</subject><issn>1433-7851</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqFkM9LwzAUx4MoTqdXj1Lw4qUzP9ol9Ta36QbTwaYHvZS0TSWjbWrSqvWvN6VzghcP4YXH53157wPAGYIDBCG-4oUUAwwRhcSndA8cIR8jl1BK9u3fI8SlzEc9cGzMxvKMweEh6GHmB9D3gyPwMlmun51RwbPGSOOo1LmXsVa5yrju2pUw185KGJW9y-LVmcisroSlPqtaC-NEjbMe3aymzqwphS7bOfnFK6mKE3CQ8syI023tg6fb6eN45i6Wd_PxaOHGng-pS3gU2W24l1CMIQtYJGiAEfIQ8zliPLHNNIYY04iLNCYiSaMkQdhjnA9ZxEkfXHa5pVZvtTBVmEsTiyzjhVC1CVEAKYSE2NcHF3_Qjaq1vbKlUBAQz5q01KCjrAhjtEjDUsuc6yZEMGyth631cGfdDpxvY-soF8kO_9FsgaADPmQmmn_iwtHDfPob_g2PNo3M</recordid><startdate>20170724</startdate><enddate>20170724</enddate><creator>Reile, Indrek</creator><creator>Aspers, Ruud L. E. G.</creator><creator>Tyburn, Jean‐Max</creator><creator>Kempf, James G.</creator><creator>Feiters, Martin C.</creator><creator>Rutjes, Floris P. J. T.</creator><creator>Tessari, Marco</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8793-0072</orcidid></search><sort><creationdate>20170724</creationdate><title>DOSY Analysis of Micromolar Analytes: Resolving Dilute Mixtures by SABRE Hyperpolarization</title><author>Reile, Indrek ; Aspers, Ruud L. E. G. ; Tyburn, Jean‐Max ; Kempf, James G. ; Feiters, Martin C. ; Rutjes, Floris P. J. T. ; Tessari, Marco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4507-3abb590a4d7220898be792114185a18ad208fc0227baefc3edfbdd1248aa68ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Dilution</topic><topic>DOSY</topic><topic>Hyperpolarization</topic><topic>Magnetic resonance spectroscopy</topic><topic>NMR spectroscopy</topic><topic>parahydrogen</topic><topic>SABRE</topic><topic>Sensitivity analysis</topic><topic>Sensitivity enhancement</topic><topic>Spectroscopic analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reile, Indrek</creatorcontrib><creatorcontrib>Aspers, Ruud L. E. G.</creatorcontrib><creatorcontrib>Tyburn, Jean‐Max</creatorcontrib><creatorcontrib>Kempf, James G.</creatorcontrib><creatorcontrib>Feiters, Martin C.</creatorcontrib><creatorcontrib>Rutjes, Floris P. J. T.</creatorcontrib><creatorcontrib>Tessari, Marco</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Angewandte Chemie International Edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reile, Indrek</au><au>Aspers, Ruud L. E. G.</au><au>Tyburn, Jean‐Max</au><au>Kempf, James G.</au><au>Feiters, Martin C.</au><au>Rutjes, Floris P. J. T.</au><au>Tessari, Marco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DOSY Analysis of Micromolar Analytes: Resolving Dilute Mixtures by SABRE Hyperpolarization</atitle><jtitle>Angewandte Chemie International Edition</jtitle><addtitle>Angew Chem Int Ed Engl</addtitle><date>2017-07-24</date><risdate>2017</risdate><volume>56</volume><issue>31</issue><spage>9174</spage><epage>9177</epage><pages>9174-9177</pages><issn>1433-7851</issn><eissn>1521-3773</eissn><abstract>DOSY is an NMR spectroscopy technique that resolves resonances according to the analytes’ diffusion coefficients. It has found use in correlating NMR signals and estimating the number of components in mixtures. Applications of DOSY in dilute mixtures are, however, held back by excessively long measurement times. We demonstrate herein, how the enhanced NMR sensitivity provided by SABRE hyperpolarization allows DOSY analysis of low‐micromolar mixtures, thus reducing the concentration requirements by at least 100‐fold.
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| subjects | Dilution DOSY Hyperpolarization Magnetic resonance spectroscopy NMR spectroscopy parahydrogen SABRE Sensitivity analysis Sensitivity enhancement Spectroscopic analysis |
| title | DOSY Analysis of Micromolar Analytes: Resolving Dilute Mixtures by SABRE Hyperpolarization |
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