R-spondin Is More Than Just Wnt’s Sidekick

R-spondin Is More Than Just Wnt’s Sidekick

The intestinal crypt and its stem cells are dependent on the Wnt pathway. Reporting in Nature, Yan et al. (2017) show that Wnts and Wnt signaling potentiator R-spondins have non-interchangeable roles. Both are necessary for intestinal stem cell (ISC) maintenance, and R-spondins are the limiting fact...

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Veröffentlicht in:Developmental cell 2017-06, Vol.41 (5), p.456-458
Hauptverfasser: Huels, David J., Sansom, Owen J.
Format: Artikel
Sprache:eng
Schlagworte:
Humans
Intestines
Stem Cells
Thrombospondins
Wnt Signaling Pathway
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Zusammenfassung:The intestinal crypt and its stem cells are dependent on the Wnt pathway. Reporting in Nature, Yan et al. (2017) show that Wnts and Wnt signaling potentiator R-spondins have non-interchangeable roles. Both are necessary for intestinal stem cell (ISC) maintenance, and R-spondins are the limiting factor that defines ISC number. The intestinal crypt and its stem cells are dependent on the Wnt pathway. Reporting in Nature, Yan et al. (2017) show that Wnts and Wnt signaling potentiator R-spondins have non-interchangeable roles. Both are necessary for intestinal stem cell (ISC) maintenance, and R-spondins are the limiting factor that defines ISC number.
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2017.05.018