Cadmium, arsenic, selenium and iron– implications for tumor progression in breast cancer

Cadmium, arsenic, selenium and iron– implications for tumor progression in breast cancer

Highlights • We analyzed contents of Cd, As, Se and Fe in 42 sets of breast cancer tissues. • Content of Cd, Se and Fe was significantly higher in tumors as compared to adjacent tissues. • Significant positive correlation between contents of Cd and As in tumors was found. • Cd content in tumors was...

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Veröffentlicht in:Environmental toxicology and pharmacology 2017-07, Vol.53, p.151-157
Hauptverfasser: Jablonska, E, Socha, K, Reszka, E, Wieczorek, E, Skokowski, J, Kalinowski, L, Fendler, W, Seroczynska, B, Wozniak, M, Borawska, M.H, Wasowicz, W
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Aged, 80 and over
Analytical methods
Arsenic
Arsenic - analysis
Breast - chemistry
Breast cancer
Breast Neoplasms - chemistry
Breast Neoplasms - pathology
Cadmium
Cadmium - analysis
Cancer
Emergency
Female
Health risks
Humans
Iron
Iron - analysis
Middle Aged
Progesterone
Selenium
Selenium - analysis
Smoking
Tissues
Tumors
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Zusammenfassung:Highlights • We analyzed contents of Cd, As, Se and Fe in 42 sets of breast cancer tissues. • Content of Cd, Se and Fe was significantly higher in tumors as compared to adjacent tissues. • Significant positive correlation between contents of Cd and As in tumors was found. • Cd content in tumors was significantly associated with tumor stage, grade and progesterone status. • Low Se level in tumor tissues was significantly associated with the presence of metastases.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2017.05.014