Keap1 knockdown in melanocytes induces cell proliferation and survival via HO-1-associated β-catenin signaling

Highlights • Nrf2-Keap1 signaling pathway protects cells against photo-oxidative stress. • Nrf2 can affect melanogenesis in addition to protecting against oxidative stress. • Keap1-silenced melanocytes showed increased melanogenesis. • This increased melanogenesis was done through HO-1-associated β-...

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Veröffentlicht in:	Journal of dermatological science 2017-10, Vol.88 (1), p.85-95
Hauptverfasser:	Kim, Ji Young, Lee, Hemin, Lee, Eun Jung, Kim, Mikyoung, Kim, Tae-Gyun, Kim, Hyoung-Pyo, Oh, Sang Ho
Format:	Artikel
Sprache:	eng
Schlagworte:	Beta catenin beta Catenin - metabolism Cell Proliferation Cell Survival Dermatology Down-Regulation Epidermis - cytology Epidermis - metabolism Gene Knockdown Techniques Heme Oxygenase-1 - genetics Heme Oxygenase-1 - metabolism HO-1 Humans Hydrogen Peroxide - toxicity Keap1 Kelch-Like ECH-Associated Protein 1 - genetics Kelch-Like ECH-Associated Protein 1 - metabolism Keratinocytes - drug effects Keratinocytes - metabolism Melanins - biosynthesis Melanocyte survival Melanocytes - metabolism Melanogenesis NF-E2-Related Factor 2 - metabolism Primary Cell Culture RNA Interference RNA sequencing RNA, Small Interfering - metabolism Signal Transduction Up-Regulation
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Zusammenfassung:	Highlights • Nrf2-Keap1 signaling pathway protects cells against photo-oxidative stress. • Nrf2 can affect melanogenesis in addition to protecting against oxidative stress. • Keap1-silenced melanocytes showed increased melanogenesis. • This increased melanogenesis was done through HO-1-associated β-catenin signaling.
ISSN:	0923-1811 1873-569X
DOI:	10.1016/j.jdermsci.2017.05.007