GHS additivity formula: A true replacement method for acute systemic toxicity testing of agrochemical formulations

Acute systemic (oral, dermal, inhalation) toxicity testing of agrochemical formulations (end-use products) is mainly needed for Classification and Labelling (C&L) and definition of personal protection equipment (PPE). A retrospective analysis of 225 formulations with available in vivo data showe...

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Veröffentlicht in:	Regulatory toxicology and pharmacology 2016-12, Vol.82, p.99-110
Hauptverfasser:	Corvaro, M., Gehen, S., Andrews, K., Chatfield, R., Arasti, C., Mehta, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	3Rs Acute toxicity Administration, Cutaneous Administration, Inhalation Administration, Oral Agrochemicals - chemistry Agrochemicals - classification Agrochemicals - toxicity Algorithms Animal Testing Alternatives - methods Animals Complex Mixtures - chemistry Complex Mixtures - classification Complex Mixtures - toxicity Databases, Chemical Dose-Response Relationship, Drug GHS Global policy change Humans Inhalation Exposure - adverse effects Lethal Dose 50 Models, Theoretical Replacement Reproducibility of Results Retrospective Studies Risk Assessment Theory of additivity Time Factors Toxicity Tests, Acute - methods
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Beschreibung
Zusammenfassung:	Acute systemic (oral, dermal, inhalation) toxicity testing of agrochemical formulations (end-use products) is mainly needed for Classification and Labelling (C&L) and definition of personal protection equipment (PPE). A retrospective analysis of 225 formulations with available in vivo data showed that: A) LD50/LC50 values were above limit doses in
ISSN:	0273-2300 1096-0295
DOI:	10.1016/j.yrtph.2016.10.007