Severe aortic stenosis in dextrocardia with situs invertus and anomalous single coronary ostium treated with transcatheter aortic valve replacement

Dextrocardia with situs inversus presents a unique anatomy with right-sided vascular system that may be associated with a number of additional cardiac and vascular malformations. A rare association is the presence of a single coronary artery ostium. To our knowledge, this is the first reported case of transcatheter aortic valve replacement using Edwards SAPIEN S3 valve in Dextrocardia patient with single coronary artery take off. •TAVR is an excellent option in high-risk patients or old patients with intermediate risk as well as inoperable in severe aortic stenosis patients.•Dextrocardia with anomalous single left main and situs inversus provides a unique anatomy that can be a real challenge to the operator and the team.•TAVR in Dextrocardia patient with single left main and situs inversus for treating severe aortic stenosis is feasible and safe.