Comparative incidence dynamics and serotypes of meningitis, bacteremic pneumonia and other-IPD in young children in the PCV era: Insights from Israeli surveillance studies

Comparative incidence dynamics and serotypes of meningitis, bacteremic pneumonia and other-IPD in young children in the PCV era: Insights from Israeli surveillance studies

Highlights • PCV7/13 impact on meningitis, bacteremic-pneumonia (BP) and other-IPD differed. • In all 3 entities, disease caused by PCV13 serotypes (VT13) declined by ∼90%. • Diseases caused by non-VT13 increased by 256%, 302% and 116%, respectively. • Meningitis patients were younger; BP had higher...

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Veröffentlicht in:Vaccine 2018-08, Vol.36 (36), p.5477-5484
Hauptverfasser: Ben-Shimol, Shalom, Givon-Lavi, Noga, Grisaru-Soen, Galia, Megged, Orli, Greenberg, David, Dagan, Ron
Format: Artikel
Sprache:eng
Schlagworte:
Age composition
Allergy and Immunology
Cerebrospinal fluid
Children
Dynamics
Health maintenance organizations
HMOs
Illnesses
Incidence
IPD – invasive pneumococcal disease
Meningitis
Pathogenesis
PCV – pneumococcal conjugate vaccine
Pediatrics
Pneumonia
Population
Sepsis
Serotypes
Streptococcus infections
Surveillance
Vaccines
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Zusammenfassung:Highlights • PCV7/13 impact on meningitis, bacteremic-pneumonia (BP) and other-IPD differed. • In all 3 entities, disease caused by PCV13 serotypes (VT13) declined by ∼90%. • Diseases caused by non-VT13 increased by 256%, 302% and 116%, respectively. • Meningitis patients were younger; BP had higher proportion of non-PCV7 serotypes. • This suggests different pathogenesis and host susceptibility between the 3 entities.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2017.05.059