Factor V Leiden paradox and the occurrence of distal vein thrombosis in a large cohort of thrombotic patients

Factor V Leiden paradox and the occurrence of distal vein thrombosis in a large cohort of thrombotic patients

Highlights • The paradox was limited to heterozygous and homozygous FVL carriers. • Double heterozygotes had a clinical presentation intermediate between FVL and prothrombin mutation single carriers. • The higher prevalence of isolated distal vein thrombosis in FVL might in part explain the presence...

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Veröffentlicht in:Thrombosis research 2017-08, Vol.156, p.20-22
Hauptverfasser: Campello, Elena, Spiezia, Luca, Valle, Fabio Dalla, Tormene, Daniela, Simioni, Paolo
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Cohort Studies
Factor V - genetics
Factor V - metabolism
Female
Hematology, Oncology and Palliative Medicine
Humans
Male
Middle Aged
Risk Factors
Venous Thrombosis - blood
Venous Thrombosis - epidemiology
Venous Thrombosis - genetics
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Beschreibung
Zusammenfassung:Highlights • The paradox was limited to heterozygous and homozygous FVL carriers. • Double heterozygotes had a clinical presentation intermediate between FVL and prothrombin mutation single carriers. • The higher prevalence of isolated distal vein thrombosis in FVL might in part explain the presence of paradox.
ISSN:0049-3848
1879-2472
DOI:10.1016/j.thromres.2017.05.025