Uncommon EGFR mutations in advanced non-small cell lung cancer

Highlights • Uncommon or ‘non-classical’ EGFR mutations, including complex mutations are increasingly reported. • Exon 20 insertions have a poor response to EGFR-TKIs • Mutations in L861Q, S768I and G718X have an inferior response to EGFR-TKIs • Complex mutations harboring an uncommon mutation have...

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2017-07, Vol.109, p.137-144
Hauptverfasser:	O’Kane, Grainne M, Bradbury, Penelope A, Feld, Ronald, Leighl, Natasha B, Liu, Geoffrey, Pisters, Katherine, Kamel-Reid, Suzanne, Tsao, Ming, Shepherd, Frances A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - therapeutic use Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Drug Resistance EGFR mutations Hematology, Oncology and Palliative Medicine Humans Incidence Lung Neoplasms - drug therapy Lung Neoplasms - genetics Mutation - genetics NSCLC Protein Kinase Inhibitors - therapeutic use Pulmonary/Respiratory Receptor, Epidermal Growth Factor - genetics Treatment Outcome Tyrosine kinase inhibitors Uncommon
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Beschreibung
Zusammenfassung:	Highlights • Uncommon or ‘non-classical’ EGFR mutations, including complex mutations are increasingly reported. • Exon 20 insertions have a poor response to EGFR-TKIs • Mutations in L861Q, S768I and G718X have an inferior response to EGFR-TKIs • Complex mutations harboring an uncommon mutation have a better response than single mutations.
ISSN:	0169-5002 1872-8332
DOI:	10.1016/j.lungcan.2017.04.016