Nontoxic outer membrane vesicles efficiently increase the efficacy of an influenza vaccine in mice and ferrets

Highlights • The fmOMV–adjuvanted vaccine showed protective effect of the in animal models. • The fmOMV with vaccine provided an efficient protection against virus challenges. • The fmOMV–adjuvanted vaccine induced Th1-type immunity. • fmOMV seems to be a promising candidate T cell adjuvant for the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2017-06, Vol.35 (30), p.3741-3748
Hauptverfasser:	Shim, Sang-Mu, Song, Eun-Jung, Song, Daesub, Lee, Tae-Young, Kim, Doo-Jin, Nam, Jeong-Hyun, Gwin Jeong, Dae, Lee, Chong-Kil, Kim, Sang-Hyun, Kim, Jeong-Ki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant Adjuvants Adjuvants, Immunologic Allergy and Immunology Alum Aluminum Aluminum sulfate Animal models Animals Antibodies, Viral - biosynthesis Antibody response Antigens Bacterial Outer Membrane Proteins - administration & dosage Bacterial Outer Membrane Proteins - immunology Bacterial Outer Membrane Proteins - toxicity Cross Protection Cytokines Dendritic cells E coli Effectiveness Escherichia coli - genetics Escherichia coli - immunology Ferrets fmOMV Homology Humoral immunity Immune response Immune response (cell-mediated) Immune system Immunity Immunity, Humoral Immunogenicity, Vaccine Infections Influenza Influenza A Virus, H1N1 Subtype - immunology Influenza Vaccines - administration & dosage Influenza Vaccines - immunology Lethal dose Lipids Lung - immunology Lung - virology Lungs Lymphocytes Lymphocytes T Membrane vesicles Mice Orthomyxoviridae Infections - prevention & control Pandemic Pandemics Phosphatase Priming T cell Th1 Cells - immunology Vaccines Viral Load Viruses
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • The fmOMV–adjuvanted vaccine showed protective effect of the in animal models. • The fmOMV with vaccine provided an efficient protection against virus challenges. • The fmOMV–adjuvanted vaccine induced Th1-type immunity. • fmOMV seems to be a promising candidate T cell adjuvant for the influenza vaccine.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2017.05.053