A holistic review on the autoimmune disease vitiligo with emphasis on the causal factors

Highlights • Vitiligo is an idiopathic systemic autoimmune disease affecting skin, hair and oral mucosa. • Melanin loss cause psychological morbidity in the patients. • Apart from thyroid disturbance, hormones like Corticotropin-releasing hormone, ACTH, MSH, melatonin, calcitriol, testosterone, estr...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2017-08, Vol.92, p.501-508
Hauptverfasser:	Patel, Seema, Rauf, Abdur, Khan, Haroon, Meher, Biswa Ranjan, Hassan, Syed Shams ul
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmune disease Autoimmune Diseases - chemically induced Autoimmune Diseases - etiology Autoimmune Diseases - metabolism Calcitriol - metabolism Cosmetics - adverse effects Cyclooxygenase 2 - metabolism Humans Internal Medicine Life Style Medical Education Melanin loss Melanins - metabolism Melanocytes - drug effects Melanocytes - metabolism Oxidative Stress - drug effects Oxidative Stress - physiology Thyroid gland Tyrosine Vitiligo Vitiligo - chemically induced Vitiligo - etiology Vitiligo - metabolism
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Beschreibung
Zusammenfassung:	Highlights • Vitiligo is an idiopathic systemic autoimmune disease affecting skin, hair and oral mucosa. • Melanin loss cause psychological morbidity in the patients. • Apart from thyroid disturbance, hormones like Corticotropin-releasing hormone, ACTH, MSH, melatonin, calcitriol, testosterone, estrogen), genes, and lifestyle choices (diet, cosmetic products) are causal of this disease. • This review discusses these under-investigated facets of vitiligo onset and progression.
ISSN:	0753-3322 1950-6007
DOI:	10.1016/j.biopha.2017.05.095