Low concentrations of neutrophil extracellular traps induce proliferation in human keratinocytes via NF-kB activation

Highlights • NETs display a negative as well as positive role in various diseases. • NETs modulate human keratinocytes behaviour through NF-kB activation. • NETs could have a physiological role in normal wound healing process.

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Veröffentlicht in:Journal of dermatological science 2017-10, Vol.88 (1), p.110-116
Hauptverfasser: Tonello, Stelvio, Rizzi, Manuela, Migliario, Mario, Rocchetti, Vincenzo, Renò, Filippo
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container_end_page 116
container_issue 1
container_start_page 110
container_title Journal of dermatological science
container_volume 88
creator Tonello, Stelvio
Rizzi, Manuela
Migliario, Mario
Rocchetti, Vincenzo
Renò, Filippo
description Highlights • NETs display a negative as well as positive role in various diseases. • NETs modulate human keratinocytes behaviour through NF-kB activation. • NETs could have a physiological role in normal wound healing process.
doi_str_mv 10.1016/j.jdermsci.2017.05.010
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subjects Adult
Amiloride - pharmacology
Cell Line
Cell Movement - drug effects
Cell Proliferation
Cell Separation
Chlorpromazine - pharmacology
Dermatology
Dexamethasone - pharmacology
DNA - metabolism
Extracellular Traps - immunology
Extracellular Traps - metabolism
Healthy Volunteers
Histones - metabolism
Humans
Inflammation
Keratinocytes
Keratinocytes - drug effects
Keratinocytes - metabolism
Keratinocytes - physiology
NETs
Neutrophils
Neutrophils - metabolism
NF-kappa B - antagonists & inhibitors
NF-kappa B - metabolism
Signal Transduction - drug effects
Wound Healing - physiology
title Low concentrations of neutrophil extracellular traps induce proliferation in human keratinocytes via NF-kB activation
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