Low concentrations of neutrophil extracellular traps induce proliferation in human keratinocytes via NF-kB activation

Highlights • NETs display a negative as well as positive role in various diseases. • NETs modulate human keratinocytes behaviour through NF-kB activation. • NETs could have a physiological role in normal wound healing process.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of dermatological science 2017-10, Vol.88 (1), p.110-116
Hauptverfasser:	Tonello, Stelvio, Rizzi, Manuela, Migliario, Mario, Rocchetti, Vincenzo, Renò, Filippo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amiloride - pharmacology Cell Line Cell Movement - drug effects Cell Proliferation Cell Separation Chlorpromazine - pharmacology Dermatology Dexamethasone - pharmacology DNA - metabolism Extracellular Traps - immunology Extracellular Traps - metabolism Healthy Volunteers Histones - metabolism Humans Inflammation Keratinocytes Keratinocytes - drug effects Keratinocytes - metabolism Keratinocytes - physiology NETs Neutrophils Neutrophils - metabolism NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism Signal Transduction - drug effects Wound Healing - physiology
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Beschreibung
Zusammenfassung:	Highlights • NETs display a negative as well as positive role in various diseases. • NETs modulate human keratinocytes behaviour through NF-kB activation. • NETs could have a physiological role in normal wound healing process.
ISSN:	0923-1811 1873-569X
DOI:	10.1016/j.jdermsci.2017.05.010