Iron chelation for the treatment of uveitis

Abstract Inflammatory eye diseases such as uveitis are common and may eventually result in vision loss. Iron can play a critical role in ocular inflammation via promoting the generation of oxygen free radicals and it is also nutritionally essential for microbial growth. Considering this involvement...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Medical hypotheses 2017-06, Vol.103, p.1-4
Hauptverfasser:	Chen, Junru, Zhou, Juan, Kelly, Mel, Holbein, Bruce E, Lehmann, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Free Radicals Homeostasis Humans Inflammation Internal Medicine Iron - adverse effects Iron Chelating Agents - therapeutic use Models, Theoretical Reactive Oxygen Species - metabolism Treatment Outcome Uveitis - drug therapy Vision Disorders - drug therapy
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Abstract Inflammatory eye diseases such as uveitis are common and may eventually result in vision loss. Iron can play a critical role in ocular inflammation via promoting the generation of oxygen free radicals and it is also nutritionally essential for microbial growth. Considering this involvement of iron in inflammation and microbial infection, we hypothesize that administration of iron chelators has potential to function as a novel therapy in uveitis and help improve clinical outcomes.
ISSN:	0306-9877 1532-2777
DOI:	10.1016/j.mehy.2017.03.029