Blockade of chondroitin sulfate proteoglycans-induced axonal growth inhibition by LOTUS
Highlights • Overexpression of LOTUS inhibits CSPG-induced growth cone collapse. • Loss of LOTUS causes growth cone collapse induced by CSPGs. • Overexpression of LOTUS rescues neurite outgrowth inhibition induced by CSPGs.
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| Veröffentlicht in: | Neuroscience 2017-07, Vol.356, p.265-274 |
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| container_end_page | 274 |
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| container_title | Neuroscience |
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| creator | Kurihara, Yuji Saito, Yu Takei, Kohtaro |
| description | Highlights • Overexpression of LOTUS inhibits CSPG-induced growth cone collapse. • Loss of LOTUS causes growth cone collapse induced by CSPGs. • Overexpression of LOTUS rescues neurite outgrowth inhibition induced by CSPGs. |
| doi_str_mv | 10.1016/j.neuroscience.2017.05.034 |
| format | Article |
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| ispartof | Neuroscience, 2017-07, Vol.356, p.265-274 |
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| language | eng |
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| subjects | Animals axon regeneration Axons - drug effects Axons - metabolism B-Cell Activating Factor - pharmacology Cells, Cultured Central Nervous System - metabolism chondroitin sulfate proteoglycans Chondroitin Sulfate Proteoglycans - antagonists & inhibitors Chondroitin Sulfate Proteoglycans - metabolism Ganglia, Spinal - drug effects Ganglia, Spinal - metabolism Growth Cones - drug effects Growth Cones - metabolism LOTUS Myelin Proteins - metabolism Myelin-Associated Glycoprotein - metabolism Neurology Nogo receptor-1 |
| title | Blockade of chondroitin sulfate proteoglycans-induced axonal growth inhibition by LOTUS |
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