Blockade of chondroitin sulfate proteoglycans-induced axonal growth inhibition by LOTUS

Highlights • Overexpression of LOTUS inhibits CSPG-induced growth cone collapse. • Loss of LOTUS causes growth cone collapse induced by CSPGs. • Overexpression of LOTUS rescues neurite outgrowth inhibition induced by CSPGs.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2017-07, Vol.356, p.265-274
Hauptverfasser:	Kurihara, Yuji, Saito, Yu, Takei, Kohtaro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals axon regeneration Axons - drug effects Axons - metabolism B-Cell Activating Factor - pharmacology Cells, Cultured Central Nervous System - metabolism chondroitin sulfate proteoglycans Chondroitin Sulfate Proteoglycans - antagonists & inhibitors Chondroitin Sulfate Proteoglycans - metabolism Ganglia, Spinal - drug effects Ganglia, Spinal - metabolism Growth Cones - drug effects Growth Cones - metabolism LOTUS Myelin Proteins - metabolism Myelin-Associated Glycoprotein - metabolism Neurology Nogo receptor-1
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Beschreibung
Zusammenfassung:	Highlights • Overexpression of LOTUS inhibits CSPG-induced growth cone collapse. • Loss of LOTUS causes growth cone collapse induced by CSPGs. • Overexpression of LOTUS rescues neurite outgrowth inhibition induced by CSPGs.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2017.05.034