Maternal exposure to polybrominated diphenyl ether (BDE-209) during lactation affects germ cell survival with altered testicular glucose homeostasis and oxidative status through down-regulation of Cx43 and p27Kip1 in prepubertal mice offspring
Highlights • Lactational exposure to BDE-209 affects germ cell survival in mice offspring. • Offspring of BDE-209-exposed dams show altered testicular glucose homeostasis. • Alteration in glucose homeostasis is primarily due to increased oxidative stress. • Altered glucose homeostasis is partly asso...
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Veröffentlicht in: | Toxicology (Amsterdam) 2017-07, Vol.386, p.103-119 |
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Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Highlights • Lactational exposure to BDE-209 affects germ cell survival in mice offspring. • Offspring of BDE-209-exposed dams show altered testicular glucose homeostasis. • Alteration in glucose homeostasis is primarily due to increased oxidative stress. • Altered glucose homeostasis is partly associated with increased E2 level. • Offspring of treated dams show decreased testicular p27Kip1 and Cx43 expressions. |
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ISSN: | 0300-483X 1879-3185 |
DOI: | 10.1016/j.tox.2017.05.016 |