Maternal exposure to polybrominated diphenyl ether (BDE-209) during lactation affects germ cell survival with altered testicular glucose homeostasis and oxidative status through down-regulation of Cx43 and p27Kip1 in prepubertal mice offspring

Highlights • Lactational exposure to BDE-209 affects germ cell survival in mice offspring. • Offspring of BDE-209-exposed dams show altered testicular glucose homeostasis. • Alteration in glucose homeostasis is primarily due to increased oxidative stress. • Altered glucose homeostasis is partly asso...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Toxicology (Amsterdam) 2017-07, Vol.386, p.103-119
Hauptverfasser: Sarkar, Debarshi, Singh, Shio Kumar
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Highlights • Lactational exposure to BDE-209 affects germ cell survival in mice offspring. • Offspring of BDE-209-exposed dams show altered testicular glucose homeostasis. • Alteration in glucose homeostasis is primarily due to increased oxidative stress. • Altered glucose homeostasis is partly associated with increased E2 level. • Offspring of treated dams show decreased testicular p27Kip1 and Cx43 expressions.
ISSN:0300-483X
1879-3185
DOI:10.1016/j.tox.2017.05.016