Circulating Proteasomes in the Pathogenesis of Head and Neck Squamous Cell Carcinoma

Increased proteasome activity was revealed in blood serum of patients with stage T1N0M0 head and neck squamous cell carcinoma in comparison with patients with chronic diseases of the larynx and laryngopharynx. This opens prospects of using chymotrypsin-like activity measurement for differential diag...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2017-05, Vol.163 (1), p.92-94
Hauptverfasser:	Kakurina, G. V., Cheremisina, O. V., Choinzonov, E. L., Kondakova, I. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Carcinoma, Squamous Cell - blood Carcinoma, Squamous Cell - pathology Cell Biology Chronic illnesses Chymotrypsin Diagnosis, Differential Differential diagnosis Female Head & neck cancer Head and Neck Neoplasms - blood Head and Neck Neoplasms - pathology Humans Internal Medicine Laboratory Medicine Larynx Male Middle Aged Neck Pathology Pharyngitis - blood Pharyngitis - pathology Proteasome Endopeptidase Complex - blood Proteasomes Risk groups Squamous cell carcinoma
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Beschreibung
Zusammenfassung:	Increased proteasome activity was revealed in blood serum of patients with stage T1N0M0 head and neck squamous cell carcinoma in comparison with patients with chronic diseases of the larynx and laryngopharynx. This opens prospects of using chymotrypsin-like activity measurement for differential diagnosis of squamous cell carcinoma, screening for high-risk groups, and evaluation of the degree of tumor differentiation
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-017-3745-7