Variations in Serum Free Thyroxine Concentration Within the Reference Range Predicts the Incidence of Metabolic Syndrome in Non-Obese Adults: A Cohort Study

Background: The association of changes in thyroid hormone values over time with the incidence of metabolic syndrome (MetS) has not yet been evaluated. For the first time, this study assessed the effect of thyroid hormone variations in the subclinical and euthyroid range on the incidence of MetS and...

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Veröffentlicht in:	Thyroid (New York, N.Y.) N.Y.), 2017-07, Vol.27 (7), p.886-893
Hauptverfasser:	Mehran, Ladan, Amouzegar, Atieh, Bakhtiyari, Mahmood, Mansournia, Mohammad Ali, Rahimabad, Parnian Kheirkhah, Tohidi, Maryam, Azizi, Fereidoun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Body Mass Index Cohort Studies Female Humans Incidence Insulin - blood Insulin Resistance - physiology Iran Lipids - blood Male Metabolic Syndrome - blood Metabolic Syndrome - epidemiology Middle Aged Original Studies Predictive Value of Tests Prospective Studies Reference Values Thyroid Dysfunction: Hypothyroidism, Thyrotoxicosis, and Thyroid Function Tests Thyroid Function Tests Thyroxine - blood Waist Circumference Young Adult
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Zusammenfassung:	Background: The association of changes in thyroid hormone values over time with the incidence of metabolic syndrome (MetS) has not yet been evaluated. For the first time, this study assessed the effect of thyroid hormone variations in the subclinical and euthyroid range on the incidence of MetS and its components over a 10-year follow-up in an adult population. Methods: Data were analyzed from the prospective population-based Tehran Thyroid Study. Of 5786 randomly selected subjects aged ≥20 years, after excluding subjects with MetS ( n = 1403), those with serum thyrotropin (TSH) >10 or
ISSN:	1050-7256 1557-9077
DOI:	10.1089/thy.2016.0557