Effect of CLU and PICALM polymorphisms on AD risk: A study from south India

Highlights • Our results confirmed significant association of APOE ε4 carrier status with AD. • No association was observed for the CLU and PICALM loci tested and AD. • It is the first study to examine two AD candidate genes ( CLU, PICALM ) in Indian population.

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Bibliographische Detailangaben
Veröffentlicht in:	Asian journal of psychiatry 2017-06, Vol.27, p.7-11
Hauptverfasser:	Shankarappa, Bhagyalakshmi Mallapura, Kota, Lakshmi Narayanan, Purushottam, Meera, Nagpal, Kavita, Mukherjee, Odity, Viswanath, Biju, Varghese, Mathew, Bharath, Srikala, Jain, Sanjeev
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alzheimer Disease - genetics Apolipoprotein E4 - genetics Clusterin - genetics Female Humans India Internal Medicine Male Middle Aged Monomeric Clathrin Assembly Proteins - genetics Polymorphism, Single Nucleotide Psychiatry Risk
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Highlights • Our results confirmed significant association of APOE ε4 carrier status with AD. • No association was observed for the CLU and PICALM loci tested and AD. • It is the first study to examine two AD candidate genes ( CLU, PICALM ) in Indian population.
ISSN:	1876-2018 1876-2026
DOI:	10.1016/j.ajp.2016.12.017