Lighting-up breast cancer cells by a near-infrared fluorescent probe based on KIAA1363 enzyme-targeting

Lighting-up breast cancer cells by a near-infrared fluorescent probe based on KIAA1363 enzyme-targeting

The first NIR KIAA1363-targeting probe, NB-AX, specifically and instantly featured an "off-on" switch upon gradual addition of KIAA1363 over all kinds of other biomolecules, and its detection limit was initially calculated to be 0.58 μg mL (3δ/k). The probe was also able to be used in ultr...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2017, Vol.53 (35), p.4857-4860
Hauptverfasser: Fan, Jiangli, Guo, Shigang, Wang, Suzhen, Kang, Yao, Yao, Qichao, Wang, Jia, Gao, Xue, Wang, Hongjiang, Du, Jianjun, Peng, Xiaojun
Format: Artikel
Sprache:eng
Schlagworte:
Biomolecules
Breast
Breast Neoplasms - diagnostic imaging
Cancer
Carboxylic Ester Hydrolases - analysis
Carboxylic Ester Hydrolases - metabolism
Female
Fluorescence
Fluorescent Dyes - analysis
Fluorescent Dyes - chemistry
Humans
Imaging
Mathematical analysis
Models, Molecular
Molecular Structure
Optical Imaging
Oxazines - chemistry
Quantum Theory
Switches
Tumors
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Zusammenfassung:The first NIR KIAA1363-targeting probe, NB-AX, specifically and instantly featured an "off-on" switch upon gradual addition of KIAA1363 over all kinds of other biomolecules, and its detection limit was initially calculated to be 0.58 μg mL (3δ/k). The probe was also able to be used in ultrafast distinguishing of breast cancer cells from normal cells in fluorescence imaging and applied in tissue imaging and tumor imaging in vivo.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc01798g