Correlation between phenotypic antibiotic susceptibility and the resistome in Pseudomonas aeruginosa

Highlights • Resistomics for 672 Pseudomonas aeruginosa strains revealed 147 loci involved in antibiotic resistance. • Integron analysis identified more than 70 different integron types. • Resistome-wide association studies scored 46 markers for resistance to four clinically used antibiotics. • Vari...

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Veröffentlicht in:	International journal of antimicrobial agents 2017-08, Vol.50 (2), p.210-218
Hauptverfasser:	Jaillard, Magali, van Belkum, Alex, Cady, Kyle C, Creely, David, Shortridge, Dee, Blanc, Bernadette, Barbu, E. Magda, Dunne, W. Michael, Zambardi, Gilles, Enright, Mark, Mugnier, Nathalie, Priol, Christophe Le, Schicklin, Stéphane, Guigon, Ghislaine, Veyrieras, Jean-Baptiste
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antibiotic resistance Drug Resistance, Bacterial Genes, Bacterial Genetic Loci Genotype Humans Infectious Disease Integrons Interspersed Repetitive Sequences Microbial Sensitivity Tests Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - genetics Pseudomonas aeruginosa - isolation & purification Pseudomonas Infections - microbiology Resistance gene mapping Resistome-wide association study RWAS
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Zusammenfassung:	Highlights • Resistomics for 672 Pseudomonas aeruginosa strains revealed 147 loci involved in antibiotic resistance. • Integron analysis identified more than 70 different integron types. • Resistome-wide association studies scored 46 markers for resistance to four clinically used antibiotics. • Variation in the oprD gene correlated well with changes in the meropenem MIC.
ISSN:	0924-8579 1872-7913
DOI:	10.1016/j.ijantimicag.2017.02.026