Burden of vaccine-preventable pneumococcal disease in hospitalized adults: A Canadian Immunization Research Network (CIRN) Serious Outcomes Surveillance (SOS) network study

Highlights • Active CAP and IPD surveillance was conducted in hospitalized adults since 2010. • Severe outcomes and mortality is seen with CAP and IPD in hospitalized adults. • The serotype distribution suggests most disease in adults is vaccine-preventable. • The incidence of vaccine-preventable pn...

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Veröffentlicht in:	Vaccine 2017-06, Vol.35 (29), p.3647-3654
Hauptverfasser:	LeBlanc, Jason J, ElSherif, May, Ye, Lingyun, MacKinnon-Cameron, Donna, Li, Li, Ambrose, Ardith, Hatchette, Todd F, Lang, Amanda L, Gillis, Hayley, Martin, Irene, Andrew, Melissa K, Boivin, Guy, Bowie, William, Green, Karen, Johnstone, Jennie, Loeb, Mark, McCarthy, Anne, McGeer, Allison, Moraca, Sanela, Semret, Makeda, Stiver, Grant, Trottier, Sylvie, Valiquette, Louis, Webster, Duncan, McNeil, Shelly A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Adults Age Aged Aged, 80 and over Allergy and Immunology Antigens Assaying Blood culture Burden Canada - epidemiology Children Communities Consent Diagnostic systems Disease Disease prevention Epidemiological Monitoring Female Hospitalization Hospitals Humans Immunization Influenza Inpatients Laboratory tests Male Mechanical ventilation Medical laboratories Medical records Middle Aged Morbidity Mortality Older people Patients Pneumococcal Pneumococcal Infections - epidemiology Pneumococcal Infections - microbiology Pneumonia Polymerase Chain Reaction Prevalence Public health Serogroup Serotype Serotypes Serotyping Sputum Streptococcus infections Streptococcus pneumoniae Streptococcus pneumoniae - classification Streptococcus pneumoniae - isolation & purification Surveillance Urine Vaccines Ventilation Young Adult
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Beschreibung
Zusammenfassung:	Highlights • Active CAP and IPD surveillance was conducted in hospitalized adults since 2010. • Severe outcomes and mortality is seen with CAP and IPD in hospitalized adults. • The serotype distribution suggests most disease in adults is vaccine-preventable. • The incidence of vaccine-preventable pneumococcal CAP by age was estimated. • Most vaccine-preventable pneumococcal disease is seen in adults aged ≥50 years.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2017.05.049