Avian influenza virus A H7N9 infects multiple mononuclear cell types in peripheral blood and induces dysregulated cytokine responses and apoptosis in infected monocytes

Avian influenza virus A H7N9 infects multiple mononuclear cell types in peripheral blood and induces dysregulated cytokine responses and apoptosis in infected monocytes

Most patients with avian influenza A H7N9 virus (H7N9) infection suffer from severe illness, accompanied by dysregulated cytokine/chemokine response, delayed viral clearance and impaired neutralizing antibody response. Here, we evaluated the role of peripheral blood mononuclear cells (PBMCs) in the...

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Veröffentlicht in:Journal of general virology 2017-05, Vol.98 (5), p.922-934
Hauptverfasser: Lee, Andrew C Y, To, Kelvin K W, Zhu, Houshun, Chu, Hin, Li, Can, Mak, Winger W N, Zhang, Anna J X, Yuen, Kwok-Yung
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
Cells, Cultured
Cytokines - secretion
Humans
Influenza A Virus, H7N9 Subtype - growth & development
Influenza A Virus, H7N9 Subtype - immunology
Influenza A Virus, H7N9 Subtype - pathogenicity
Leukocytes, Mononuclear - virology
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Zusammenfassung:Most patients with avian influenza A H7N9 virus (H7N9) infection suffer from severe illness, accompanied by dysregulated cytokine/chemokine response, delayed viral clearance and impaired neutralizing antibody response. Here, we evaluated the role of peripheral blood mononuclear cells (PBMCs) in the pathogenesis of H7N9 infection using an ex vivo infection model. H7N9 infected a significantly higher percentage of PBMCs (23.9 %) than those of avian influenza A H5N1 virus (H5N1) (12.3 %) and pandemic H1N1 virus (pH1N1) (5.5 %) (P
ISSN:0022-1317
1465-2099
DOI:10.1099/jgv.0.000751