Sex differences in the neuroendocrine control of metabolism and the implication of astrocytes

Highlights • In experimentally induced obesity models, females are generally less susceptible to weight gain. • Females have a more delayed development of obesity associated complications. • Early influences can modify metabolism in a sexually dimorphic manner. • Hypothalamic astrocytes from males a...

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Veröffentlicht in:	Frontiers in neuroendocrinology 2018-01, Vol.48, p.3-12
Hauptverfasser:	Chowen, Julie A, Argente-Arizón, Pilar, Freire-Regatillo, Alejandra, Argente, Jesús
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes Astrocytes - metabolism Endocrinology & Metabolism Fatty acids Female Glia Gonadal Steroid Hormones - metabolism Humans Hypothalamus Hypothalamus - metabolism Inflammation Male Metabolism Obesity - metabolism Sex Characteristics Sex steroids
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Beschreibung
Zusammenfassung:	Highlights • In experimentally induced obesity models, females are generally less susceptible to weight gain. • Females have a more delayed development of obesity associated complications. • Early influences can modify metabolism in a sexually dimorphic manner. • Hypothalamic astrocytes from males and females respond differently to metabolic signals.
ISSN:	0091-3022 1095-6808
DOI:	10.1016/j.yfrne.2017.05.003