Thrombotic thrombocytopenic purpura related to ADAMTS13 deficiency, and successful treatment in a chimpanzee (Pan troglodytes verus)

Thrombotic thrombocytopenic purpura related to ADAMTS13 deficiency, and successful treatment in a chimpanzee (Pan troglodytes verus)

A 27-year-old male chimpanzee (Pan troglodytes verus) developed signs of thrombotic thrombocytopenic purpura (TTP). ADAMTS13 deficiency appeared to be the cause of disease. After treatment with high-dose prednisone, haematological values and clinical signs recovered. This is the first description of...

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Veröffentlicht in:Journal of medical primatology 2017, Vol.46 (5), p.267-270
Hauptverfasser: van Bolhuis, Hester, Wolters, Marno, de Boer, Mark, Fijnheer, Rob, van Zijll Langhout, Martine, Niphuis, Henk, Eckmann, Carel
Format: Report
Sprache:eng
Online-Zugang:Volltext
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Zusammenfassung:A 27-year-old male chimpanzee (Pan troglodytes verus) developed signs of thrombotic thrombocytopenic purpura (TTP). ADAMTS13 deficiency appeared to be the cause of disease. After treatment with high-dose prednisone, haematological values and clinical signs recovered. This is the first description of spontaneous TTP associated with ADAMTS13 deficiency in a non-human primate.
ISSN:1600-0684
DOI:10.1111/jmp.12278