MicroRNA-101 in the ventrolateral orbital cortex (VLO) modulates depressive-like behaviors in rats and targets dual-specificity phosphatase 1 (DUSP1)
Highlights • Chronic stress decreased miR-101 levels and increased DUSP1 levels in VLO. • Intra-VLO treatment with miR-101 mimic reversed depressive-like behaviors in rats. • MiR-101 downregulates DUSP1 expression and promoted downstream ERK/BDNF signaling. • Evidence for miR-101 modulation of stres...
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| Veröffentlicht in: | Brain research 2017-08, Vol.1669, p.55-62 |
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| container_title | Brain research |
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| creator | Zhao, Yan Wang, Shuang Chu, Zheng Dang, Yonghui Zhu, Juanxia Su, Xingli |
| description | Highlights • Chronic stress decreased miR-101 levels and increased DUSP1 levels in VLO. • Intra-VLO treatment with miR-101 mimic reversed depressive-like behaviors in rats. • MiR-101 downregulates DUSP1 expression and promoted downstream ERK/BDNF signaling. • Evidence for miR-101 modulation of stress responses via ERK/BDNF signaling in VLO. |
| doi_str_mv | 10.1016/j.brainres.2017.05.020 |
| format | Article |
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Wang, Shuang ; Chu, Zheng ; Dang, Yonghui ; Zhu, Juanxia ; Su, Xingli</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-83ed7c3913a612ed13840e87a57dcba24a4ee32089e2fed1401e5230208b5e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Antidepressive Agents - pharmacology</topic><topic>Brain-Derived Neurotrophic Factor - metabolism</topic><topic>Chronic Disease</topic><topic>Chronic unpredictable mild stress (CUMS)</topic><topic>Depression</topic><topic>Depressive Disorder - drug therapy</topic><topic>Depressive Disorder - metabolism</topic><topic>Disease Models, Animal</topic><topic>Dual specificity phosphatase 1 (DUSP1)</topic><topic>Dual Specificity Phosphatase 1 - metabolism</topic><topic>Extracellular Signal-Regulated MAP Kinases - metabolism</topic><topic>Male</topic><topic>microRNAs</topic><topic>MicroRNAs - metabolism</topic><topic>miR-101</topic><topic>Neurology</topic><topic>Phosphorylation</topic><topic>Prefrontal Cortex - drug effects</topic><topic>Prefrontal Cortex - metabolism</topic><topic>Random Allocation</topic><topic>Rats, Sprague-Dawley</topic><topic>Stress, Psychological - drug therapy</topic><topic>Stress, Psychological - metabolism</topic><topic>Uncertainty</topic><topic>Ventrolateral orbital cortex (VLO)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Yan</creatorcontrib><creatorcontrib>Wang, Shuang</creatorcontrib><creatorcontrib>Chu, Zheng</creatorcontrib><creatorcontrib>Dang, Yonghui</creatorcontrib><creatorcontrib>Zhu, Juanxia</creatorcontrib><creatorcontrib>Su, Xingli</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Yan</au><au>Wang, Shuang</au><au>Chu, Zheng</au><au>Dang, Yonghui</au><au>Zhu, Juanxia</au><au>Su, Xingli</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MicroRNA-101 in the ventrolateral orbital cortex (VLO) modulates depressive-like behaviors in rats and targets dual-specificity phosphatase 1 (DUSP1)</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2017-08-15</date><risdate>2017</risdate><volume>1669</volume><spage>55</spage><epage>62</epage><pages>55-62</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><abstract>Highlights • Chronic stress decreased miR-101 levels and increased DUSP1 levels in VLO. • Intra-VLO treatment with miR-101 mimic reversed depressive-like behaviors in rats. • MiR-101 downregulates DUSP1 expression and promoted downstream ERK/BDNF signaling. • Evidence for miR-101 modulation of stress responses via ERK/BDNF signaling in VLO.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28549965</pmid><doi>10.1016/j.brainres.2017.05.020</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Antidepressive Agents - pharmacology Brain-Derived Neurotrophic Factor - metabolism Chronic Disease Chronic unpredictable mild stress (CUMS) Depression Depressive Disorder - drug therapy Depressive Disorder - metabolism Disease Models, Animal Dual specificity phosphatase 1 (DUSP1) Dual Specificity Phosphatase 1 - metabolism Extracellular Signal-Regulated MAP Kinases - metabolism Male microRNAs MicroRNAs - metabolism miR-101 Neurology Phosphorylation Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Random Allocation Rats, Sprague-Dawley Stress, Psychological - drug therapy Stress, Psychological - metabolism Uncertainty Ventrolateral orbital cortex (VLO) |
| title | MicroRNA-101 in the ventrolateral orbital cortex (VLO) modulates depressive-like behaviors in rats and targets dual-specificity phosphatase 1 (DUSP1) |
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