MicroRNA-101 in the ventrolateral orbital cortex (VLO) modulates depressive-like behaviors in rats and targets dual-specificity phosphatase 1 (DUSP1)

Highlights • Chronic stress decreased miR-101 levels and increased DUSP1 levels in VLO. • Intra-VLO treatment with miR-101 mimic reversed depressive-like behaviors in rats. • MiR-101 downregulates DUSP1 expression and promoted downstream ERK/BDNF signaling. • Evidence for miR-101 modulation of stres...

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Veröffentlicht in:	Brain research 2017-08, Vol.1669, p.55-62
Hauptverfasser:	Zhao, Yan, Wang, Shuang, Chu, Zheng, Dang, Yonghui, Zhu, Juanxia, Su, Xingli
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressive Agents - pharmacology Brain-Derived Neurotrophic Factor - metabolism Chronic Disease Chronic unpredictable mild stress (CUMS) Depression Depressive Disorder - drug therapy Depressive Disorder - metabolism Disease Models, Animal Dual specificity phosphatase 1 (DUSP1) Dual Specificity Phosphatase 1 - metabolism Extracellular Signal-Regulated MAP Kinases - metabolism Male microRNAs MicroRNAs - metabolism miR-101 Neurology Phosphorylation Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Random Allocation Rats, Sprague-Dawley Stress, Psychological - drug therapy Stress, Psychological - metabolism Uncertainty Ventrolateral orbital cortex (VLO)
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Zusammenfassung:	Highlights • Chronic stress decreased miR-101 levels and increased DUSP1 levels in VLO. • Intra-VLO treatment with miR-101 mimic reversed depressive-like behaviors in rats. • MiR-101 downregulates DUSP1 expression and promoted downstream ERK/BDNF signaling. • Evidence for miR-101 modulation of stress responses via ERK/BDNF signaling in VLO.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/j.brainres.2017.05.020