Fluvoxamine maleate effects on dopamine signaling in the prefrontal cortex of stressed Parkinsonian rats: Implications for learning and memory

Highlights • Maternal separation caused learning and memory impairment. • Fluvoxamine maleate (FM) reversed learning and memory impairment. • FM protected DA and 5-HT signaling in the prefrontal cortex.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain research bulletin 2017-06, Vol.132, p.75-81
Hauptverfasser:	Dallé, Ernest, Daniels, Willie M.U, Mabandla, Musa V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cognitive impairment Corticosterone - blood Dopamine Dopamine - metabolism Fluvoxamine - pharmacology Learning - drug effects Learning - physiology Learning Disorders - drug therapy Learning Disorders - metabolism Lipid Peroxidation - drug effects Lipid Peroxidation - physiology Male Maternal Deprivation Memory - drug effects Memory - physiology Memory Disorders - drug therapy Memory Disorders - metabolism Neurology Neurotransmitter Agents - pharmacology Nootropic Agents - pharmacology Oxidopamine Parkinsonian Disorders - drug therapy Parkinsonian Disorders - metabolism Parkinsonian Disorders - psychology Parkinson’s disease Prefrontal cortex Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Random Allocation Rats, Sprague-Dawley Serotonin Serotonin - metabolism Stress, Psychological - metabolism
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Beschreibung
Zusammenfassung:	Highlights • Maternal separation caused learning and memory impairment. • Fluvoxamine maleate (FM) reversed learning and memory impairment. • FM protected DA and 5-HT signaling in the prefrontal cortex.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2017.05.014