High virulence of methicillin resistant Staphylococcus aureus ST30-SCCmecIVc-spat019, the dominant community-associated clone in Argentina

Community-acquired methicillin resistant Staphylococcus aureus emerged as a worldwide health problem in the last few years. In Argentina, it is found in 70% of skin and skin structure infections in previously healthy adult patients and causes severe invasive diseases. The ST30-SCCmecIVc-spat019 clon...

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Veröffentlicht in:International journal of medical microbiology 2017-06, Vol.307 (4-5), p.191-199
Hauptverfasser: Fernandez, Silvina, Ledo, Camila, Lattar, Santiago, Noto Llana, Mariángeles, Bertelli, Andrea Mendoza, Di Gregorio, Sabrina, Sordelli, Daniel O., Gómez, Marisa I., Mollerach, Marta E.
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Sprache:eng
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Zusammenfassung:Community-acquired methicillin resistant Staphylococcus aureus emerged as a worldwide health problem in the last few years. In Argentina, it is found in 70% of skin and skin structure infections in previously healthy adult patients and causes severe invasive diseases. The ST30-SCCmecIVc-spat019 clone is predominant in adult infections and has displaced the previously prevalent ST5-SCCmecIVa-spat311 clone in community settings. In the present work we compared the virulence of both clones in order to explain the displacement, and found that ST30-IVc is associated with invasive infections in adult patients from Argentina and possesses a different virulence-associated genes profile compared to ST5-IVa. A representative strain of ST30 lineage has a more aggressive behavior in animal models of infection and expresses higher level of Fibronectin binding protein A coding gene, which could enhance the bacterial invasion capacity.
ISSN:1438-4221
1618-0607
DOI:10.1016/j.ijmm.2017.05.003