Systematic review and meta-analysis of the effect of metformin treatment on overall mortality rates in women with endometrial cancer and type 2 diabetes mellitus

Highlights • We performed the first meta-analysis to examine the effect of metformin on mortality in endometrial cancer. • Metformin use is associated with a significant reduction in overall mortality. • The findings suggest that good glycemic control may improve survival in endometrial cancer. • La...

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Veröffentlicht in:	Maturitas 2017-07, Vol.101, p.6-11
Hauptverfasser:	Perez-Lopez, Faustino R, Pasupuleti, Vinay, Gianuzzi, Ximena, Palma-Ardiles, Gabriela, Hernandez-Fernandez, Wendy, Hernandez, Adrian V
Format:	Artikel
Sprache:	eng
Schlagworte:	Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - mortality Endometrial cancer Endometrial Neoplasms - drug therapy Endometrial Neoplasms - mortality Female Humans Hypoglycemic Agents - therapeutic use Internal Medicine Metformin Metformin - therapeutic use Obstetrics and Gynecology Overall mortality Retrospective Studies Type 2 diabetes mellitus
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Zusammenfassung:	Highlights • We performed the first meta-analysis to examine the effect of metformin on mortality in endometrial cancer. • Metformin use is associated with a significant reduction in overall mortality. • The findings suggest that good glycemic control may improve survival in endometrial cancer. • Larger observational studies are needed to confirm this finding.
ISSN:	0378-5122 1873-4111
DOI:	10.1016/j.maturitas.2017.04.001