Lot-to-lot consistency, safety and immunogenicity of 3 lots of Haemophilus influenzae type b conjugate vaccine: results from a phase III randomized, multicenter study in infants

Highlights • The study vaccine (Hib-TT) administered according to a 3 + 1 schedule is immunogenic. • Immune responses to Hib-TT vaccination and to licensed Hib vaccines are comparable. • Hib-TT primary and booster vaccination safety profiles are similar to other Hib vaccines. • Immune response to ro...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2017-06, Vol.35 (28), p.3564-3574
Hauptverfasser:	Klein, Nicola P, Abu-Elyazeed, Remon, Cornish, Matthew, Leonardi, Michael L, Weiner, Leonard B, Silas, Peter E, Grogg, Stanley E, Varman, Meera, Frenck, Robert W, Cheuvart, Brigitte, Baine, Yaela, Miller, Jacqueline M, Leyssen, Maarten, Mesaros, Narcisa, Roy-Ghanta, Sumita
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Allergy and Immunology Antibodies, Bacterial - blood Antigens Bacterial Capsules - immunology Booster Children Consent Consistency Drug dosages Female Haemophilus Infections - epidemiology Haemophilus Infections - immunology Haemophilus Infections - prevention & control Haemophilus influenzae type b Haemophilus influenzae type b - immunology Haemophilus Vaccines - administration & dosage Haemophilus Vaccines - adverse effects Haemophilus Vaccines - chemistry Haemophilus Vaccines - immunology Hepatitis Hiberix Humans Immune response Immunization Immunization Schedule Immunization, Secondary Immunogenicity Immunogenicity, Vaccine Incidence Infant Infants Licenses Male Objectives Pediatrics Primary immunization Randomization Safety Shortages Tetanus Tetanus Toxoid - administration & dosage Tetanus Toxoid - adverse effects Tetanus Toxoid - immunology United States - epidemiology Vaccines Vaccines, Conjugate - administration & dosage Vaccines, Conjugate - adverse effects Vaccines, Conjugate - chemistry Vaccines, Conjugate - immunology Viruses Whooping cough
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • The study vaccine (Hib-TT) administered according to a 3 + 1 schedule is immunogenic. • Immune responses to Hib-TT vaccination and to licensed Hib vaccines are comparable. • Hib-TT primary and booster vaccination safety profiles are similar to other Hib vaccines. • Immune response to routine vaccines is not impacted by co-administration with Hib-TT.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2017.05.018