Improved oral bioavailability and brain accumulation of afatinib due to dual inhibition of the efflux mechanisms of BCRP and Pgp transporters —What next?

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Veröffentlicht in:	Pharmacological research 2017-09, Vol.123, p.143-143
1. Verfasser:	Srinivas, Nuggehally R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacokinetics ATP Binding Cassette Transporter, Sub-Family G, Member 2 - metabolism ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Biological Availability Brain - metabolism Humans Neoplasm Proteins - metabolism Quinazolines - metabolism Quinazolines - pharmacokinetics Radiation-Sensitizing Agents - metabolism Radiation-Sensitizing Agents - pharmacokinetics
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